STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemXSimilar to Escherichia coli putative uroporphyrin-III C-methyltransferase HemX or b3803 SWALL:HEMX_ECOLI (SWALL:P09127) (393 aa) fasta scores: E(): 5.1e-71, 60.54% id in 370 aa. (374 aa)    
Predicted Functional Partners:
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.998
hemY
Porphyrin biosynthetic protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri HemY protein HemY or b3802 or c4721 or z5316 or ecs4732 or sf3874 SWALL:HEMY_ECOLI (SWALL:P09128) (398 aa) fasta scores: E(): 1.3e-109, 73.02% id in 393 aa, and to Salmonella typhi porphyrin biosynthetic protein sty3624 SWALL:Q8Z398 (EMBL:AL627279) (399 aa) fasta scores: E(): 7e-108, 71.24% id in 393 aa.
 
  
 0.990
nirE
Similar to Paracoccus denitrificans uroporphyrin-III C-methyltransferase NirE SWALL:NIRE_PARDE (SWALL:Q51701) (287 aa) fasta scores: E(): 2.3e-41, 49.6% id in 256 aa, and to Vibrio cholerae uroporphyrin-III C-methyltransferase vc2561 SWALL:Q9KP18 (EMBL:AE004324) (299 aa) fasta scores: E(): 1.6e-48, 58.15% id in 239 aa; Belongs to the precorrin methyltransferase family.
     
 0.971
cysG1
Siroheme synthase [includes: uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
     
 0.971
cysG2
Siroheme synthase [includes: uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
     
 0.971
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.947
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 
 0.891
lolB
Outer-membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
  
     0.733
cyaA
Adenylate cyclase; Similar to Erwinia chrysanthemi adenylate cyclase Cya SWALL:CYAA_ERWCH (SWALL:P40130) (851 aa) fasta scores: E(): 0, 89.33% id in 853 aa, and to Escherichia coli adenylate cyclase CyaA or Cya or b3806 SWALL:CYAA_ECOLI (SWALL:P00936) (848 aa) fasta scores: E(): 0, 82.19% id in 848 aa; Belongs to the adenylyl cyclase class-1 family.
 
    0.714
ECA4182
Similar to Yersinia pestis hypothetical protein ypo3844 or y0386 SWALL:Q8ZAF8 (EMBL:AJ414159) (234 aa) fasta scores: E(): 1.8e-68, 73.93% id in 234 aa, and to Salmonella typhi hypothetical protein Sty3611 SWALL:Q8Z3A7 (EMBL:AL627279) (235 aa) fasta scores: E(): 4.6e-60, 64.68% id in 235 aa.
 
    0.697
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.