Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemYPorphyrin biosynthetic protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri HemY protein HemY or b3802 or c4721 or z5316 or ecs4732 or sf3874 SWALL:HEMY_ECOLI (SWALL:P09128) (398 aa) fasta scores: E(): 1.3e-109, 73.02% id in 393 aa, and to Salmonella typhi porphyrin biosynthetic protein sty3624 SWALL:Q8Z398 (EMBL:AL627279) (399 aa) fasta scores: E(): 7e-108, 71.24% id in 393 aa. (397 aa)    
Predicted Functional Partners:
hemX
Similar to Escherichia coli putative uroporphyrin-III C-methyltransferase HemX or b3803 SWALL:HEMX_ECOLI (SWALL:P09127) (393 aa) fasta scores: E(): 5.1e-71, 60.54% id in 370 aa.
 
  
 0.990
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
   
 0.946
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
  
 0.821
lolB
Outer-membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
 
     0.772
cyaA
Adenylate cyclase; Similar to Erwinia chrysanthemi adenylate cyclase Cya SWALL:CYAA_ERWCH (SWALL:P40130) (851 aa) fasta scores: E(): 0, 89.33% id in 853 aa, and to Escherichia coli adenylate cyclase CyaA or Cya or b3806 SWALL:CYAA_ECOLI (SWALL:P00936) (848 aa) fasta scores: E(): 0, 82.19% id in 848 aa; Belongs to the adenylyl cyclase class-1 family.
 
     0.721
ECA1145
Similar to Yersinia pestis putative lipoprotein ypo3161 or y1024 SWALL:AAM84605 (EMBL:AJ414155) (192 aa) fasta scores: E(): 7.8e-54, 80.2% id in 192 aa, and to Salmonella typhi putative lipoprotein sty0487 SWALL:Q8Z8V2 (EMBL:AL627266) (192 aa) fasta scores: E(): 2.3e-47, 68.75% id in 192 aa.
  
     0.720
hemF
Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
    
 0.698
wecF
4-alpha-L-fucosyltransferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family.
  
     0.697
atpI
ATP synthase protein I; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri ATP synthase protein I AtpI or UncI or b3739 or c4667 or sf3819 SWALL:ATPZ_ECOLI (SWALL:P03808) (125 aa) fasta scores: E(): 5.7e-21, 57.02% id in 121 aa.
  
     0.692
wzyE
Putative ECA polymerase; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family.
  
     0.690
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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