STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvDSimilar to Escherichia coli dihydroxy-acid dehydratase IlvD or b3771 SWALL:ILVD_ECOLI (SWALL:P05791) (616 aa) fasta scores: E(): 9.7e-207, 87.98% id in 616 aa; Belongs to the IlvD/Edd family. (616 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.996
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.996
ECA2971
Putative branched-chain amino acid aminotransferase; Similar to Listeria monocytogenes D-alanine aminotransferase Dat or DaaA or lmo1619 SWALL:DAAA_LISMO (SWALL:O85046) (289 aa) fasta scores: E(): 2.2e-24, 35.21% id in 284 aa, and to Methanopyrus kandleri branched-chain amino acid aminotransferase ilve or mk1627 SWALL:Q8TUX5 (EMBL:AE010451) (295 aa) fasta scores: E(): 6.5e-30, 34.05% id in 276 aa.
  
 0.981
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
     
 0.961
ECA3033
Probable aminotransferase; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri probable aminotransferase yfbq or b2290 or c2831 or sf2366 SWALL:YFBQ_ECOLI (SWALL:P77727) (405 aa) fasta scores: E(): 1.8e-148, 89.6% id in 404 aa, and to Salmonella typhi putative aminotransferase t0533 SWALL:AAO68239 (EMBL:AE016836) (404 aa) fasta scores: E(): 2.3e-150, 91.58% id in 404 aa.
   
 
 0.950
avtA
Similar to Escherichia coli valine--pyruvate aminotransferase AvtA or b3572 SWALL:AVTA_ECOLI (SWALL:P09053) (417 aa) fasta scores: E(): 9.4e-133, 77.34% id in 415 aa.
     
 0.945
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
 
 
 0.938
ilvM
Acetolactate synthase isozyme II small subunit; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri acetolactate synthase isozyme II small subunit IlvM or b3769 or c4691 or sf3844 SWALL:ILVM_ECOLI (SWALL:P13048) (86 aa) fasta scores: E(): 1.8e-18, 63.52% id in 85 aa.
  
  
 0.931
ilvG
Similar to Escherichia coli acetolactate synthase isozyme II large subunit IlvG or b3767 SWALL:ILVG_ECOLI (SWALL:P00892) (548 aa) fasta scores: E(): 9.5e-169, 80.22% id in 546 aa.
 
 0.930
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.928
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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