STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA4231Conserved hypothetical protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri protein yife or b3764 or c4686 or z5276 or ecs4699 or sf3840 SWALL:AAN45278 (EMBL:M87049) (112 aa) fasta scores: E(): 2.1e-36, 79.46% id in 112 aa, and to Yersinia pestis hypothetical protein Ypo3903 SWALL:Q8ZAA8 (EMBL:AJ414159) (112 aa) fasta scores: E(): 7.3e-36, 81.25% id in 112 aa. (112 aa)    
Predicted Functional Partners:
lptC
Putative exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.697
rraB
Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
     0.680
ECA4182
Similar to Yersinia pestis hypothetical protein ypo3844 or y0386 SWALL:Q8ZAF8 (EMBL:AJ414159) (234 aa) fasta scores: E(): 1.8e-68, 73.93% id in 234 aa, and to Salmonella typhi hypothetical protein Sty3611 SWALL:Q8Z3A7 (EMBL:AL627279) (235 aa) fasta scores: E(): 4.6e-60, 64.68% id in 235 aa.
  
     0.668
syd
Putative SecY-interacting protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family.
  
     0.666
metJ
Repressor of the methionine regulon; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family.
  
    0.658
yihI
Conserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family.
  
     0.646
nlpI
Lipoprotein; May be involved in cell division.
  
     0.641
rseA
sigma-E factor negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
  
     0.640
slyX
Conserved hypothetical protein; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 SlyX protein slyx or b3348 or c4122 or z4706 or ecs4199 SWALL:SLYX_ECOLI (SWALL:P30857) (72 aa) fasta scores: E(): 5.2e-12, 59.72% id in 72 aa, and to Yersinia pestis host factor for lysis of phix174 infection SlyX or y3976 SWALL:AAM87520 (EMBL:AE014001) (72 aa) fasta scores: E(): 1.5e-13, 63.88% id in 72 aa; Belongs to the SlyX family.
  
    0.632
nfi
Endonuclease V (pseudogene); 1 probable transmembrane helix predicted for ECA0236 by TMHMM2.0 at aa 102-124.
  
     0.630
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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