STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dgoKSimilar to Escherichia coli 2-dehydro-3-deoxygalactonokinase DgoK or b3693 SWALL:DGOK_ECOLI (SWALL:P31459) (292 aa) fasta scores: E(): 3.5e-61, 54.76% id in 294 aa. (298 aa)    
Predicted Functional Partners:
dgoA2
Similar to the N-terminal region of Escherichia coli DgoA protein [includes: 2-dehydro-3-deoxyphosphogalactonate aldolase; galactonate dehydratase] DgoA or DgoD or b3692 SWALL:DGOA_ECOLI (SWALL:P31458) (587 aa) fasta scores: E(): 1.3e-38, 61.08% id in 203 aa, and similar, over the entire length, to Xanthomonas axonopodis 4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase DgoA or xac1766 SWALL:Q8PLM9 (EMBL:AE011808) (210 aa) fasta scores: E(): 2.8e-38, 56.63% id in 196 aa.
 
 
 0.998
dgoA1
DgoA protein [includes: 2-dehydro-3-deoxyphosphogalactonate aldolase; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate.
 
 0.996
ECA2965
Putative mandelate racemase / muconate lactonizing enzyme; Similar to Streptomyces coelicolor putative isomerase sco3475 or sce65.11c or sce56.11C SWALL:Q9RKG2 (EMBL:AL939116) (377 aa) fasta scores: E(): 1.1e-43, 39.08% id in 394 aa, and to Oceanobacillus iheyensis hypothetical protein ob2215 SWALL:BAC14171 (EMBL:AP004600) (382 aa) fasta scores: E(): 6.9e-41, 36.36% id in 396 aa.
 
 0.964
dgoR
Similar to Escherichia coli galactonate operon transcriptional repressor DgoR or b3694/b3695 SWALL:DGOR_ECOLI (SWALL:P31460) (229 aa) fasta scores: E(): 6.9e-70, 80.61% id in 227 aa; putative GntR-family transcriptional regulator.
  
 0.960
ECA0189
Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
 
 
 0.818
rspA
Putative starvation sensing mandelate racemase / muconate lactonizing enzyme; Similar to Escherichia coli starvation sensing protein RspA SWALL:RSPA_ECOLI (SWALL:P38104) (404 aa) fasta scores: E(): 5.7e-163, 92.57% id in 404 aa. Also similar to ECA0189 (36.070% id. in 402 aa overlap).
 
 
 0.651
ECA4405
Conserved hypothetical protein; Similar to Salmonella typhi putative ATP/GTP-binding protein sty3967 SWALL:Q8Z2M0 (EMBL:AL627280) (408 aa) fasta scores: E(): 1.1e-44, 61.39% id in 417 aa, and to Escherichia coli hypothetical protein yidr or b3689 SWALL:YIDR_ECOLI (SWALL:P31455) (416 aa) fasta scores: E(): 7.8e-40, 61.08% id in 406 aa.
 
      0.568
LfeW
Similar to Salmonella typhimurium putative mandelate racemase / muconate lactonizing enzyme family stm3697 SWALL:Q8ZL58 (EMBL:AE008872) (398 aa) fasta scores: E(): 9.9e-148, 92.96% id in 398 aa, and to Pseudomonas putida mandelate racemase mdlA SWALL:MANR_PSEPU (SWALL:P11444) (359 aa) fasta scores: E(): 1.3e-22, 28.32% id in 353 aa.
 
 
 0.489
ECA4077
Putative mandelate racemase / muconate lactonizing enzyme; Similar to Agrobacterium tumefaciens isomerase/lactonizing enzyme atu3453 or agr_l_2751 SWALL:Q8UAC1 (EMBL:AE009275) (407 aa) fasta scores: E(): 1.1e-110, 65.17% id in 379 aa, and to Sulfolobus tokodaii putative dgoa protein st2366 SWALL:Q96Y01 (EMBL:AP000989) (396 aa) fasta scores: E(): 2.9e-21, 27.64% id in 369 aa; Belongs to the mandelate racemase/muconate lactonizing enzyme family.
 
 
 0.434
ECA1747
Conserved hypothetical protein; Similar to Escherichia coli O157:H7 orf, hypothetical protein yebe or z2897 or ecs2556 SWALL:Q8XCK2 (EMBL:AE005407) (219 aa) fasta scores: E(): 5e-42, 57% id in 214 aa, and to Shigella flexneri orf, conserved hypothetical protein yebe or sf1857 SWALL:AAN43415 (EMBL:AE015204) (219 aa) fasta scores: E(): 3.1e-41, 56.07% id in 214 aa.
  
     0.408
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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