Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
glmUBifunctional GlmU protein [includes: UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferas [...] (456 aa)    
Predicted Functional Partners:
mrsA
Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
 
  
 0.993
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
 
  
 0.988
glmS
Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
  
 0.977
wecB
UDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
    
 0.969
rfbM
Similar to Escherichia coli mannose-1-phosphate guanylyltransferase ManC or CpsB or RfbM or b2049 SWALL:MANC_ECOLI (SWALL:P24174) (478 aa) fasta scores: E(): 2.1e-114, 60.88% id in 473 aa, and to Shigella flexneri mannose-1-phosphate guanyltransferase CpsB_1 or sf2112 SWALL:AAN43651 (EMBL:AE015227) (478 aa) fasta scores: E(): 5.5e-115, 61.31% id in 473 aa; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.967
galE
Similar to Escherichia coli udp-glucose 4-epimerase GalE or GalD or b0759 SWALL:GALE_ECOLI (SWALL:P09147) (338 aa) fasta scores: E(): 5.5e-102, 76.03% id in 338 aa; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
   
 0.966
ugd
Similar to Escherichia coli UDP-glucose 6-dehydrogenase Ugd or b2028 SWALL:UDG_ECOLI (SWALL:P76373) (388 aa) fasta scores: E(): 2.4e-110, 73.96% id in 388 aa, and to Vibrio cholerae nucleotide sugar dehydrogenase SWALL:Q56625 (EMBL:U47057) (388 aa) fasta scores: E(): 1e-110, 72.93% id in 388 aa.
    
 0.965
lpxA
acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
    
 0.962
rfbA
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
    
 0.958
galF
Similar to Escherichia coli, and Escherichia coli O157:H7 UTP--glucose-1-phosphate uridylyltransferase GalF or WcaN or b2042 or z3205 or ecs2846 SWALL:GALF_ECOLI (SWALL:P78083) (297 aa) fasta scores: E(): 7.1e-74, 65.43% id in 298 aa, and to Salmonella typhimurium, and Salmonella typhi UTP--glucose-1-phosphate uridylyltransferase GalF or stm2098 or sty2308 SWALL:GALF_SALTY (SWALL:P26390) (297 aa) fasta scores: E(): 7.1e-74, 64.43% id in 298 aa.
 
  
 0.947
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.