| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | dapB | SBG_3623 | SBG_0048 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Ribonucleoside hydrolase 3 (remnant); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.728 |
| birA | folK | SBG_3623 | SBG_0180 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | 0.681 |
| birA | hfQ | SBG_3623 | SBG_3805 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Host factor-I protein(HF-I); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.533 |
| birA | metG | SBG_3623 | SBG_1968 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.677 |
| birA | mgsA | SBG_3623 | SBG_0877 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. | 0.804 |
| birA | pcnB | SBG_3623 | SBG_0181 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.734 |
| dapB | birA | SBG_0048 | SBG_3623 | Ribonucleoside hydrolase 3 (remnant); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.728 |
| dapB | metG | SBG_0048 | SBG_1968 | Ribonucleoside hydrolase 3 (remnant); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.561 |
| dapB | mgsA | SBG_0048 | SBG_0877 | Ribonucleoside hydrolase 3 (remnant); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. | 0.729 |
| dapB | pcnB | SBG_0048 | SBG_0181 | Ribonucleoside hydrolase 3 (remnant); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.686 |
| folK | birA | SBG_0180 | SBG_3623 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.681 |
| folK | pcnB | SBG_0180 | SBG_0181 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.951 |
| folK | yadB | SBG_0180 | SBG_0182 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | glutamyl-tRNA synthetase-related protein; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.545 |
| hfQ | birA | SBG_3805 | SBG_3623 | Host factor-I protein(HF-I); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.533 |
| hfQ | pcnB | SBG_3805 | SBG_0181 | Host factor-I protein(HF-I); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.943 |
| hfQ | pnp | SBG_3805 | SBG_2912 | Host factor-I protein(HF-I); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Polynucleotide phosphorylase. | 0.980 |
| hfQ | rhlB | SBG_3805 | SBG_3458 | Host factor-I protein(HF-I); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Putative ATP-dependent RNA helicase; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. | 0.856 |
| hfQ | rne | SBG_3805 | SBG_1025 | Host factor-I protein(HF-I); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Ribonuclease E. | 0.983 |
| metG | birA | SBG_1968 | SBG_3623 | methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.677 |
| metG | dapB | SBG_1968 | SBG_0048 | methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Ribonucleoside hydrolase 3 (remnant); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.561 |