STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpAATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (758 aa)    
Predicted Functional Partners:
clpS
ATP-dependent clp protease adaptor protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
 
 
 0.998
clpP
ATP-dependent clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
 
 0.986
dnaK
DnaK protein (heat shock protein 70).
 
 
 0.791
hscA
Chaperone protein HscA.
  
 
 0.757
yegD
Conserved hypothetical protein.
  
 
 0.743
cbpA
Curved DNA-binding protein.
  
 
 0.742
clpX
ATP-dependent clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
  
 
 0.723
htpG
Heat shock protein HtpG.
  
 
 0.712
grpE
Heat shock protein GrpE (heat shock protein b25.3) (hsp24); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the rea [...]
  
 
 0.709
dnaJ
DnaJ protein.
  
 
 0.707
Your Current Organism:
Salmonella bongori
NCBI taxonomy Id: 218493
Other names: S. bongori NCTC 12419, Salmonella bongori NCTC 12419, Salmonella bongori str. NCTC 12419, Salmonella bongori strain NCTC 12419
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