STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sopBCell invasion protein; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicl [...] (560 aa)    
Predicted Functional Partners:
sipA
Pathogenicity island 1 effector protein (function unknown).
   
  
 0.999
sipC
Pathogenicity island 1 effector protein.
   
  
 0.998
sipB
Pathogenicity island 1 effector protein.
   
  
 0.998
spaT
Unknown function.
   
  
 0.994
sopE2
Invasion-associated type III secreted effector protein.
   
  
 0.992
sipD
Pathogenicity island 1 effector protein.
   
  
 0.988
prgH
Pathogenicity 1 island effector protein.
   
  
 0.984
pipC,
Cell invasion protein chaperone.
  
  
 0.983
sboA
Candidate type three secretion system effector protein; Sequence similarity to SopA.
   
  
 0.949
sopD
Putative secreted protein.
   
  
 0.920
Your Current Organism:
Salmonella bongori
NCBI taxonomy Id: 218493
Other names: S. bongori NCTC 12419, Salmonella bongori NCTC 12419, Salmonella bongori str. NCTC 12419, Salmonella bongori strain NCTC 12419
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.