| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | nudJ | SBG_3623 | SBG_1071 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative mutT family protein; Belongs to the Nudix hydrolase family. | 0.545 |
| birA | purB | SBG_3623 | SBG_1068 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Adenylosuccinate lyase. | 0.678 |
| birA | trmU | SBG_3623 | SBG_1070 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase. | 0.415 |
| birA | yjeF | SBG_3623 | SBG_3800 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...] | 0.619 |
| hemM | nudJ | SBG_1638 | SBG_1071 | Outer membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | Putative mutT family protein; Belongs to the Nudix hydrolase family. | 0.461 |
| hemM | yfhD | SBG_1638 | SBG_2341 | Outer membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | Putative exported protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | 0.444 |
| hflD | icdA | SBG_1069 | SBG_1073 | Conserved hypothetical protein. | Isocitrate dehydrogenase. | 0.441 |
| hflD | nudJ | SBG_1069 | SBG_1071 | Conserved hypothetical protein. | Putative mutT family protein; Belongs to the Nudix hydrolase family. | 0.617 |
| hflD | purB | SBG_1069 | SBG_1068 | Conserved hypothetical protein. | Adenylosuccinate lyase. | 0.886 |
| hflD | rluB | SBG_1069 | SBG_1072 | Conserved hypothetical protein. | Putative ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.582 |
| hflD | trmU | SBG_1069 | SBG_1070 | Conserved hypothetical protein. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase. | 0.897 |
| icdA | hflD | SBG_1073 | SBG_1069 | Isocitrate dehydrogenase. | Conserved hypothetical protein. | 0.441 |
| icdA | nudJ | SBG_1073 | SBG_1071 | Isocitrate dehydrogenase. | Putative mutT family protein; Belongs to the Nudix hydrolase family. | 0.603 |
| icdA | purB | SBG_1073 | SBG_1068 | Isocitrate dehydrogenase. | Adenylosuccinate lyase. | 0.884 |
| icdA | rluB | SBG_1073 | SBG_1072 | Isocitrate dehydrogenase. | Putative ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.569 |
| icdA | trmU | SBG_1073 | SBG_1070 | Isocitrate dehydrogenase. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase. | 0.484 |
| nudJ | birA | SBG_1071 | SBG_3623 | Putative mutT family protein; Belongs to the Nudix hydrolase family. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.545 |
| nudJ | hemM | SBG_1071 | SBG_1638 | Putative mutT family protein; Belongs to the Nudix hydrolase family. | Outer membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | 0.461 |
| nudJ | hflD | SBG_1071 | SBG_1069 | Putative mutT family protein; Belongs to the Nudix hydrolase family. | Conserved hypothetical protein. | 0.617 |
| nudJ | icdA | SBG_1071 | SBG_1073 | Putative mutT family protein; Belongs to the Nudix hydrolase family. | Isocitrate dehydrogenase. | 0.603 |