| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| accD | dedD | SBG_2148 | SBG_2146 | acetyl-CoA carboxylase beta subunit. | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | 0.664 |
| accD | folC | SBG_2148 | SBG_2147 | acetyl-CoA carboxylase beta subunit. | Folylpolyglutamate synthase. | 0.799 |
| accD | trpC | SBG_2148 | SBG_1587 | acetyl-CoA carboxylase beta subunit. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.582 |
| accD | truA | SBG_2148 | SBG_2150 | acetyl-CoA carboxylase beta subunit. | tRNA pseudouridine synthase A. | 0.600 |
| dedD | accD | SBG_2146 | SBG_2148 | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | acetyl-CoA carboxylase beta subunit. | 0.664 |
| dedD | folC | SBG_2146 | SBG_2147 | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | Folylpolyglutamate synthase. | 0.908 |
| dedD | truA | SBG_2146 | SBG_2150 | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | tRNA pseudouridine synthase A. | 0.564 |
| folA | folB | SBG_0075 | SBG_2796 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.547 |
| folA | folC | SBG_0075 | SBG_2147 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase. | 0.945 |
| folA | folE | SBG_0075 | SBG_2005 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | GTP cyclohydrolase I. | 0.465 |
| folA | folK | SBG_0075 | SBG_0180 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | 0.510 |
| folA | folP | SBG_0075 | SBG_2923 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.836 |
| folA | thyA | SBG_0075 | SBG_2606 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthetase. | 0.996 |
| folB | folA | SBG_2796 | SBG_0075 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.547 |
| folB | folC | SBG_2796 | SBG_2147 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Folylpolyglutamate synthase. | 0.787 |
| folB | folE | SBG_2796 | SBG_2005 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase I. | 0.974 |
| folB | folK | SBG_2796 | SBG_0180 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | 0.997 |
| folB | folP | SBG_2796 | SBG_2923 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
| folC | accD | SBG_2147 | SBG_2148 | Folylpolyglutamate synthase. | acetyl-CoA carboxylase beta subunit. | 0.799 |
| folC | dedD | SBG_2147 | SBG_2146 | Folylpolyglutamate synthase. | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | 0.908 |