| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SBG_2701 | rdgB | SBG_2701 | SBG_2703 | Putative membrane protein. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.867 |
| SBG_2701 | yggS | SBG_2701 | SBG_2700 | Putative membrane protein. | Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.928 |
| SBG_2701 | yggU | SBG_2701 | SBG_2702 | Putative membrane protein. | Conserved hypothetical protein; Belongs to the UPF0235 family. | 0.897 |
| SBG_2701 | yggW | SBG_2701 | SBG_2704 | Putative membrane protein. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.864 |
| SBG_2706 | yggW | SBG_2706 | SBG_2704 | Conserved hypothetical protein. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.878 |
| gltB | porB | SBG_2960 | SBG_1488 | Glutamate synthase [NADPH] large chain precursor. | Putative pyruvate-flavodoxin oxidoreductase. | 0.967 |
| gltB | yggW | SBG_2960 | SBG_2704 | Glutamate synthase [NADPH] large chain precursor. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.665 |
| miaB | porB | SBG_0568 | SBG_1488 | MiaB protein (putative tRNA-thiotransferase (or tRNA-methylthiotransferase)). | Putative pyruvate-flavodoxin oxidoreductase. | 0.594 |
| miaB | yfgB | SBG_0568 | SBG_2301 | MiaB protein (putative tRNA-thiotransferase (or tRNA-methylthiotransferase)). | Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. | 0.749 |
| miaB | yggW | SBG_0568 | SBG_2704 | MiaB protein (putative tRNA-thiotransferase (or tRNA-methylthiotransferase)). | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.641 |
| porB | gltB | SBG_1488 | SBG_2960 | Putative pyruvate-flavodoxin oxidoreductase. | Glutamate synthase [NADPH] large chain precursor. | 0.967 |
| porB | miaB | SBG_1488 | SBG_0568 | Putative pyruvate-flavodoxin oxidoreductase. | MiaB protein (putative tRNA-thiotransferase (or tRNA-methylthiotransferase)). | 0.594 |
| porB | yggS | SBG_1488 | SBG_2700 | Putative pyruvate-flavodoxin oxidoreductase. | Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.832 |
| porB | yggW | SBG_1488 | SBG_2704 | Putative pyruvate-flavodoxin oxidoreductase. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.717 |
| porB | yieN | SBG_1488 | SBG_3432 | Putative pyruvate-flavodoxin oxidoreductase. | Conserved hypothetical protein. | 0.445 |
| rdgB | SBG_2701 | SBG_2703 | SBG_2701 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative membrane protein. | 0.867 |
| rdgB | yggS | SBG_2703 | SBG_2700 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. | 0.846 |
| rdgB | yggU | SBG_2703 | SBG_2702 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Conserved hypothetical protein; Belongs to the UPF0235 family. | 0.864 |
| rdgB | yggW | SBG_2703 | SBG_2704 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.945 |
| yfgB | miaB | SBG_2301 | SBG_0568 | Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. | MiaB protein (putative tRNA-thiotransferase (or tRNA-methylthiotransferase)). | 0.749 |