| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SBG_2565 | folK | SBG_2565 | SBG_0180 | Putative metal-dependent hydrolase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | 0.900 |
| SBG_2565 | folP | SBG_2565 | SBG_2923 | Putative metal-dependent hydrolase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.911 |
| folA | folC | SBG_0075 | SBG_2147 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase. | 0.943 |
| folA | folP | SBG_0075 | SBG_2923 | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.888 |
| folB | folC | SBG_2796 | SBG_2147 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Folylpolyglutamate synthase. | 0.911 |
| folB | folE | SBG_2796 | SBG_2005 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase I. | 0.982 |
| folB | folK | SBG_2796 | SBG_0180 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | 0.998 |
| folB | folP | SBG_2796 | SBG_2923 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.998 |
| folB | ftsH | SBG_2796 | SBG_2924 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Cell division protein; Belongs to the AAA ATPase family. | 0.472 |
| folB | pabC | SBG_2796 | SBG_1036 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 4-amino-4-deoxychorismate lyase. | 0.432 |
| folC | folA | SBG_2147 | SBG_0075 | Folylpolyglutamate synthase. | Dihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.943 |
| folC | folB | SBG_2147 | SBG_2796 | Folylpolyglutamate synthase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.911 |
| folC | folE | SBG_2147 | SBG_2005 | Folylpolyglutamate synthase. | GTP cyclohydrolase I. | 0.639 |
| folC | folK | SBG_2147 | SBG_0180 | Folylpolyglutamate synthase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | 0.739 |
| folC | folP | SBG_2147 | SBG_2923 | Folylpolyglutamate synthase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.998 |
| folE | folB | SBG_2005 | SBG_2796 | GTP cyclohydrolase I. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.982 |
| folE | folC | SBG_2005 | SBG_2147 | GTP cyclohydrolase I. | Folylpolyglutamate synthase. | 0.639 |
| folE | folK | SBG_2005 | SBG_0180 | GTP cyclohydrolase I. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. | 0.995 |
| folE | folP | SBG_2005 | SBG_2923 | GTP cyclohydrolase I. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.945 |
| folE | ftsH | SBG_2005 | SBG_2924 | GTP cyclohydrolase I. | Cell division protein; Belongs to the AAA ATPase family. | 0.635 |