| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bioB | birA | SBG_0683 | SBG_3623 | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.967 |
| bioB | bisC | SBG_0683 | SBG_3240 | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.900 |
| birA | bioB | SBG_3623 | SBG_0683 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.967 |
| birA | bisC | SBG_3623 | SBG_3240 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.900 |
| bisC | bioB | SBG_3240 | SBG_0683 | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.900 |
| bisC | birA | SBG_3240 | SBG_3623 | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.900 |
| bisC | gltB | SBG_3240 | SBG_2960 | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Glutamate synthase [NADPH] large chain precursor. | 0.561 |
| bisC | napB | SBG_3240 | SBG_2053 | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Cytochrome c-type protein NapB precursor; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. | 0.564 |
| bisC | napC | SBG_3240 | SBG_2052 | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Cytochrome c-type protein NapC. | 0.605 |
| bisC | pbpC | SBG_3240 | SBG_2307 | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Penicillin-binding protein 1C. | 0.831 |
| bisC | porB | SBG_3240 | SBG_1488 | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Putative pyruvate-flavodoxin oxidoreductase. | 0.593 |
| bisC | torC | SBG_3240 | SBG_3384 | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Cytochrome c-type protein; Also significantly similar to SBG2025 49% identity in 366 aa overlap. | 0.634 |
| bisC | torC2 | SBG_3240 | SBG_2025 | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Cytochrome c-type protein; Also significantly similar to SBG3384 49% identity in 366 aa overlap. | 0.688 |
| bisC | yedY | SBG_3240 | SBG_2995 | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Conserved hypothetical protein. | 0.621 |
| gltB | bisC | SBG_2960 | SBG_3240 | Glutamate synthase [NADPH] large chain precursor. | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.561 |
| gltB | porB | SBG_2960 | SBG_1488 | Glutamate synthase [NADPH] large chain precursor. | Putative pyruvate-flavodoxin oxidoreductase. | 0.967 |
| napB | bisC | SBG_2053 | SBG_3240 | Cytochrome c-type protein NapB precursor; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. | Biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.564 |
| napB | napC | SBG_2053 | SBG_2052 | Cytochrome c-type protein NapB precursor; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. | Cytochrome c-type protein NapC. | 0.999 |
| napB | torC | SBG_2053 | SBG_3384 | Cytochrome c-type protein NapB precursor; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. | Cytochrome c-type protein; Also significantly similar to SBG2025 49% identity in 366 aa overlap. | 0.923 |
| napB | torC2 | SBG_2053 | SBG_2025 | Cytochrome c-type protein NapB precursor; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. | Cytochrome c-type protein; Also significantly similar to SBG3384 49% identity in 366 aa overlap. | 0.923 |