| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| coaD | gmk | SBG_3307 | SBG_3321 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.529 |
| coaD | yicC_1 | SBG_3307 | SBG_3316 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Conserved hypothetical protein. | 0.567 |
| gltB | gmk | SBG_2960 | SBG_3321 | Glutamate synthase [NADPH] large chain precursor. | 5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.454 |
| gltB | yicC_1 | SBG_2960 | SBG_3316 | Glutamate synthase [NADPH] large chain precursor. | Conserved hypothetical protein. | 0.670 |
| gmk | coaD | SBG_3321 | SBG_3307 | 5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.529 |
| gmk | gltB | SBG_3321 | SBG_2960 | 5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Glutamate synthase [NADPH] large chain precursor. | 0.454 |
| gmk | pyrE | SBG_3321 | SBG_3314 | 5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.410 |
| gmk | rpoZ | SBG_3321 | SBG_3322 | 5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.960 |
| gmk | yicC_1 | SBG_3321 | SBG_3316 | 5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Conserved hypothetical protein. | 0.605 |
| pyrE | gmk | SBG_3314 | SBG_3321 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.410 |
| pyrE | rph | SBG_3314 | SBG_3315 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | RNase PH. | 0.800 |
| pyrE | yicC_1 | SBG_3314 | SBG_3316 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Conserved hypothetical protein. | 0.562 |
| rph | pyrE | SBG_3315 | SBG_3314 | RNase PH. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.800 |
| rph | yicC_1 | SBG_3315 | SBG_3316 | RNase PH. | Conserved hypothetical protein. | 0.589 |
| rpoZ | gmk | SBG_3322 | SBG_3321 | DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.960 |
| rpoZ | yicC_1 | SBG_3322 | SBG_3316 | DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | Conserved hypothetical protein. | 0.471 |
| yicC_1 | coaD | SBG_3316 | SBG_3307 | Conserved hypothetical protein. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.567 |
| yicC_1 | gltB | SBG_3316 | SBG_2960 | Conserved hypothetical protein. | Glutamate synthase [NADPH] large chain precursor. | 0.670 |
| yicC_1 | gmk | SBG_3316 | SBG_3321 | Conserved hypothetical protein. | 5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.605 |
| yicC_1 | pyrE | SBG_3316 | SBG_3314 | Conserved hypothetical protein. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.562 |