Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SUB0192Response regulator protein. (229 aa)    
Predicted Functional Partners:
SUB0191
Sensor histidine kinase.
 
 
 0.980
SUB0202
Sensor histidine kinase.
 
 
 0.890
phoR
Similar to the C-terminal region of Bacillus subtilis alkaline phosphatase synthesis sensor protein PhoR UniProt:PHOR_BACSU (EMBL:AF008220) (579 aa) fasta scores: E()=2.8e-31, 36.164% id in 365 aa, and to the full length Streptococcus pneumoniae histidine kinase PnpS UniProt:Q9X4S9_STRPN (EMBL:AF118229) (422 aa) fasta scores: E()=2.3e-77, 57.494% id in 407 aa.
 
 
 0.857
vicK
Sensor histidine kinase.
 
 
 0.838
csrS
Sensor histidine kinase.
 
 
 0.792
ciaH
Sensor histidine kinase.
 
 
 0.787
SUB0916
Sensor histidine kinase.
 
 
 0.766
SUB0193
Hypothetical protein; No significant database matches. Doubtful CDS.
       0.603
SUB0190
Putative exported protein.
       0.587
rpoD
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.461
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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