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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SUB0203Response regulator protein. (227 aa)    
Predicted Functional Partners:
SUB0202
Sensor histidine kinase.
 
 0.975
phoR
Similar to the C-terminal region of Bacillus subtilis alkaline phosphatase synthesis sensor protein PhoR UniProt:PHOR_BACSU (EMBL:AF008220) (579 aa) fasta scores: E()=2.8e-31, 36.164% id in 365 aa, and to the full length Streptococcus pneumoniae histidine kinase PnpS UniProt:Q9X4S9_STRPN (EMBL:AF118229) (422 aa) fasta scores: E()=2.3e-77, 57.494% id in 407 aa.
 
 0.893
SUB0191
Sensor histidine kinase.
 
 
 0.884
vicK
Sensor histidine kinase.
 
 0.867
SUB0916
Sensor histidine kinase.
 
 
 0.846
csrS
Sensor histidine kinase.
 
 
 0.833
ciaH
Sensor histidine kinase.
 
 
 0.833
SUB0205
Permease protein.
     
 0.712
SUB0204
ABC transporter ATP-binding protein.
     
 0.692
SUB0206
Putative exported protein.
       0.458
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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