STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiDPutative phosphomethylpyrimidine kinase. (255 aa)    
Predicted Functional Partners:
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
    0.873
SUB0319
Putative membrane protein.
     
 0.833
SUB0320
Conserved hypothetical protein; Belongs to the UPF0340 family.
       0.752
SUB0316
Putative aspartokinase; Belongs to the aspartokinase family.
     
 0.663
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.595
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
   
 0.531
SUB1122
FAD dependent oxidoreductase.
  
  
 0.437
ftsY
Putative cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
 
  
 0.422
SUB0460
Putative membrane protein; Possible gene remnant. Weakly similar to Photorhabdus luminescens (subsp. laumondii) ribose transport system permease protein RbsC UniProt:Q7NA78_PHOLL (EMBL:BX571859) (323 aa) fasta scores: E()=3.8, 30.928% id in 97 aa.
  
    0.400
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.