STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iscUNifU-like protein; In S. thermophilus iscU mutant displayed increased sensitivity to superoxide radicals compared to the wild type. IscU is likely to play a major role in oxidative stress defense, possibly resulting from its role in [Fe-S] cluster assembly and/or repair. (149 aa)    
Predicted Functional Partners:
csdB
Putative cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.
 
 0.999
sufD
Conserved hypothetical protein; In S. thermophilus sufD mutant displayed increased sensitivity to superoxide radicals compared to the wild type. SufD is likely to play a major role in oxidative stress defense, possibly resulting from its role in [Fe-S] cluster assembly and/or repair.
 
  
 0.995
sufB
Conserved hypothetical protein.
 
  
 0.983
SUB0721
Putative cysteine desulfhydrase.
 
 0.970
SUB0849
Putative cysteine desulfurase.
 
 0.970
sufC
Putative ABC transporter, ATP-binding protein.
  
  
 0.959
dnaK
Chaperone protein DnaK (heat shock protein 70); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.894
SUB0808
Pyridine nucleotide-disulphide oxidoreductase family protein; N-terminal region is similar to Methanococcus jannaschii putative NADH oxidase UniProt:NAOX_METJA (EMBL:MJU67512) (463 aa) fasta scores: E()=2.2e-44, 34.667% id in 450 aa. Full length CDS is similar to Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase UniProt:Q8A513_BACTN (EMBL:AE016936) (826 aa) fasta scores: E()=2.2e-125, 47.545% id in 835 aa; Belongs to the sulfur carrier protein TusA family.
  
  
 0.747
SUB0693
Conserved hypothetical protein.
  
  
 0.674
mecA
Adapter protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
       0.537
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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