STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
clpPPutative ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (196 aa)    
Predicted Functional Partners:
clpX
ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 0.998
clpE
Putative ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.
 
 
 0.970
clpC
Putative stress response-related Clp ATPase; Belongs to the ClpA/ClpB family.
 
 
 0.967
clpL
Putative ATP-dependent protease ATP-binding subunit ClpL; Belongs to the ClpA/ClpB family.
 
 
 0.961
SUB1803
Full length CDS is similar to similar to Azoarcus sp. (strain EbN1) fusion of 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase UniProt:Q5P607_AZOSE (EMBL:CR555306) (671 aa) fasta scores: E()=4.2e-35, 28.299% id in 682 aa. N-terminal region is similar to Homo sapiens (Human) short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor UniProt:HCDH_HUMAN (EMBL:HSAF1902) (314 aa) fasta scores: E()=3.3e-22, 37.687% id in 268 aa.
  
 0.950
groEL
Putative surface-anchored protein (pseudogene); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.845
groES
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.821
grpE
GrpE protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...]
  
 
 0.763
dnaK
Chaperone protein DnaK (heat shock protein 70); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.756
ftsH
Putative cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
 
 0.706
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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