Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hisCPutative histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (352 aa)    
Predicted Functional Partners:
SUB0651
Haloacid dehalogenase-like hydrolase; Similar to Shigella flexneri phosphoserine phosphatase SerB UniProt:SERB_ECOLI (EMBL:AE016993) (322 aa) fasta scores: E()=2.9e-24, 46.117% id in 206 aa, and to the full length Streptococcus thermophilus (strain ATCC BAA-250/LMG 18311) phosphoserine phosphatase SerB UniProt:Q5M3B3_STRTR (215 aa) fasta scores: E()=2.2e-46, 68.224% id in 214 aa.
 
  
 0.803
SUB0638
Putative extracellular amino acid-binding protein; Similar to SUB0688, 59.245% identity (59.470% ungapped) in 265 aa overlap (1-264:1-265).
     
 0.783
aroF
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
  
 0.624
cmk
Cytidylate kinase.
 
    0.610
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
  
 0.598
SUB0316
Putative aspartokinase; Belongs to the aspartokinase family.
 
  
 0.581
SUB0636
Conserved hypothetical protein.
       0.543
SUB0637
Acetyltransferase (GNAT) family protein.
       0.538
argH
Argininosuccinate lyase.
 
  
 0.497
SUB0398
Pyridoxal-dependent decarboxylase.
 
 
 
 0.462
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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