Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mvaA3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (426 aa)    
Predicted Functional Partners:
mvaS
3-hydroxy-3-methylglutaryl coenzyme A synthase.
 
 0.998
mvaK1
Putative surface-anchored 5'-nucleotidase (pseudogene); HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 9.5e-11.
 0.997
fni
Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.852
mvaD
Mevalonate diphosphate decarboxylase.
 
  
 0.841
mvaK2
Phosphomevalonate kinase.
 
 
 0.737
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.565
SUB0102
UbiA prenyltransferase family protein.
   
 
 0.554
atoB2
acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.
 
  
 0.550
SUB0914
Putative NUDIX hydrolase.
  
  
 0.471
SUB0108
Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
  
 
 0.430
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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