STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mvaA3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (426 aa)    
Predicted Functional Partners:
mvaS
3-hydroxy-3-methylglutaryl coenzyme A synthase.
 
 0.999
mvaK1
Putative surface-anchored 5'-nucleotidase (pseudogene); HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 9.5e-11.
 0.997
fni
Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.859
mvaD
Mevalonate diphosphate decarboxylase.
 
  
 0.854
mvaK2
Phosphomevalonate kinase.
 
 
 0.745
SUB0102
UbiA prenyltransferase family protein.
   
 
 0.685
atoB2
acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.
 
  
 0.563
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.559
SUB0914
Putative NUDIX hydrolase.
  
  
 0.545
dyr
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.447
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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