STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SUB0787Integrase; CDS is extended at the C-terminus in comparison to orthologues. Possible frameshift mutation in the C-terminus. Similar to SUB0805, 56.021% identity (56.021% ungapped) in 382 aa overlap (4-385:8-389); Belongs to the 'phage' integrase family. (410 aa)    
Predicted Functional Partners:
SUB0786
Conserved hypothetical protein.
     
 0.808
SUB0785
Putative plasmid replication protein; Similar to SUB1608, 72.043% identity (72.043% ungapped) in 186 aa overlap (1-186:1-186).
     
 0.681
SUB0789
Putative replication initiator protein.
 
   
 0.534
SUB0783
Putative FtsK/SpoIIIE family protein.
     
 0.453
SUB0784
Putative membrane protein.
       0.445
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.444
SUB0782
Conserved hypothetical protein.
       0.443
xpt
Putative xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
    0.432
SUB0788
Conserved hypothetical protein.
       0.412
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.