| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SUB0026 | apt | SUB0026 | SUB1128 | Putative phosphoribosylformylglycinamidine synthase protein. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.678 |
| SUB0026 | gmk | SUB0026 | SUB1391 | Putative phosphoribosylformylglycinamidine synthase protein. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.658 |
| SUB0026 | guaA | SUB0026 | SUB0891 | Putative phosphoribosylformylglycinamidine synthase protein. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.981 |
| SUB0026 | guaB | SUB0026 | SUB1862 | Putative phosphoribosylformylglycinamidine synthase protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.920 |
| SUB0026 | guaC | SUB0026 | SUB0865 | Putative phosphoribosylformylglycinamidine synthase protein. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.688 |
| SUB0026 | hpt | SUB0026 | SUB0014 | Putative phosphoribosylformylglycinamidine synthase protein. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.503 |
| SUB0026 | purA | SUB0026 | SUB0152 | Putative phosphoribosylformylglycinamidine synthase protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.960 |
| SUB0026 | purB | SUB0026 | SUB0056 | Putative phosphoribosylformylglycinamidine synthase protein. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.964 |
| SUB0026 | purH | SUB0026 | SUB0030 | Putative phosphoribosylformylglycinamidine synthase protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; C-terminal region is similar to SUB0037A, 88.333% identity (88.333% ungapped) in 60 aa overlap (456-515:1-60). | 0.971 |
| SUB0026 | xpt | SUB0026 | SUB0866 | Putative phosphoribosylformylglycinamidine synthase protein. | Putative xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.678 |
| apt | SUB0026 | SUB1128 | SUB0026 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative phosphoribosylformylglycinamidine synthase protein. | 0.678 |
| apt | gmk | SUB1128 | SUB1391 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.944 |
| apt | guaA | SUB1128 | SUB0891 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.979 |
| apt | guaB | SUB1128 | SUB1862 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.492 |
| apt | guaC | SUB1128 | SUB0865 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.930 |
| apt | hpt | SUB1128 | SUB0014 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.929 |
| apt | purA | SUB1128 | SUB0152 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.509 |
| apt | purB | SUB1128 | SUB0056 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.947 |
| apt | purH | SUB1128 | SUB0030 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; C-terminal region is similar to SUB0037A, 88.333% identity (88.333% ungapped) in 60 aa overlap (456-515:1-60). | 0.946 |
| apt | xpt | SUB1128 | SUB0866 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.922 |