| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SUB0026 | guaA | SUB0026 | SUB0891 | Putative phosphoribosylformylglycinamidine synthase protein. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.996 |
| SUB0026 | guaB | SUB0026 | SUB1862 | Putative phosphoribosylformylglycinamidine synthase protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.955 |
| SUB0026 | guaC | SUB0026 | SUB0865 | Putative phosphoribosylformylglycinamidine synthase protein. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.663 |
| SUB0026 | pbuX | SUB0026 | SUB0867 | Putative phosphoribosylformylglycinamidine synthase protein. | Putative xanthine permease. | 0.603 |
| SUB0026 | pyrB | SUB0026 | SUB0733 | Putative phosphoribosylformylglycinamidine synthase protein. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.724 |
| SUB0026 | pyrC | SUB0026 | SUB1016 | Putative phosphoribosylformylglycinamidine synthase protein. | Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.552 |
| SUB0026 | pyrE | SUB0026 | SUB1024 | Putative phosphoribosylformylglycinamidine synthase protein. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.840 |
| SUB0026 | pyrF | SUB0026 | SUB1025 | Putative phosphoribosylformylglycinamidine synthase protein. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.779 |
| SUB0026 | pyrR | SUB0026 | SUB0731 | Putative phosphoribosylformylglycinamidine synthase protein. | PyrR bifunctional protein [includes: pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.580 |
| SUB0026 | xpt | SUB0026 | SUB0866 | Putative phosphoribosylformylglycinamidine synthase protein. | Putative xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.648 |
| guaA | SUB0026 | SUB0891 | SUB0026 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Putative phosphoribosylformylglycinamidine synthase protein. | 0.996 |
| guaA | guaB | SUB0891 | SUB1862 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | guaC | SUB0891 | SUB0865 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.996 |
| guaA | pbuX | SUB0891 | SUB0867 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Putative xanthine permease. | 0.676 |
| guaA | pyrB | SUB0891 | SUB0733 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.673 |
| guaA | pyrC | SUB0891 | SUB1016 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.608 |
| guaA | pyrE | SUB0891 | SUB1024 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.743 |
| guaA | pyrF | SUB0891 | SUB1025 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.758 |
| guaA | pyrR | SUB0891 | SUB0731 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | PyrR bifunctional protein [includes: pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.586 |
| guaA | xpt | SUB0891 | SUB0866 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Putative xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.984 |
