node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SUB1549 | SUB1683 | SUB1549 | SUB1683 | Putative cytidine and deoxycytidylate deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.942 |
SUB1549 | tdk | SUB1549 | SUB0870 | Putative cytidine and deoxycytidylate deaminase. | Putative thymidine kinase. | 0.931 |
SUB1549 | thyA | SUB1549 | SUB0771 | Putative cytidine and deoxycytidylate deaminase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.937 |
SUB1549 | tmk | SUB1549 | SUB0438 | Putative cytidine and deoxycytidylate deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.931 |
SUB1683 | SUB1549 | SUB1683 | SUB1549 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Putative cytidine and deoxycytidylate deaminase. | 0.942 |
SUB1683 | tdk | SUB1683 | SUB0870 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Putative thymidine kinase. | 0.958 |
SUB1683 | thyA | SUB1683 | SUB0771 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.959 |
SUB1683 | tmk | SUB1683 | SUB0438 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.938 |
cdd | deoA | SUB0951 | SUB0953 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine phosphorylase. | 0.997 |
cdd | deoD | SUB0951 | SUB1046 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Putative purine nucleoside phosphorylase. | 0.931 |
cdd | punA | SUB0951 | SUB1047 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Putative purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.930 |
cdd | tdk | SUB0951 | SUB0870 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Putative thymidine kinase. | 0.927 |
deoA | cdd | SUB0953 | SUB0951 | Thymidine phosphorylase. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.997 |
deoA | deoD | SUB0953 | SUB1046 | Thymidine phosphorylase. | Putative purine nucleoside phosphorylase. | 0.937 |
deoA | punA | SUB0953 | SUB1047 | Thymidine phosphorylase. | Putative purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.939 |
deoA | tdk | SUB0953 | SUB0870 | Thymidine phosphorylase. | Putative thymidine kinase. | 0.925 |
deoD | cdd | SUB1046 | SUB0951 | Putative purine nucleoside phosphorylase. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.931 |
deoD | deoA | SUB1046 | SUB0953 | Putative purine nucleoside phosphorylase. | Thymidine phosphorylase. | 0.937 |
deoD | punA | SUB1046 | SUB1047 | Putative purine nucleoside phosphorylase. | Putative purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.958 |
deoD | tdk | SUB1046 | SUB0870 | Putative purine nucleoside phosphorylase. | Putative thymidine kinase. | 0.929 |