Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SUB0875Conserved hypothetical protein. (325 aa)    
Predicted Functional Partners:
SUB0876
Putative membrane protein; Similar to Pneumococcal vaccine antigen A protein.
 
   
 0.860
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
       0.835
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
       0.793
prmC
Putative methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
       0.793
SUB0873
Conserved hypothetical protein; Belongs to the SUA5 family.
       0.793
tdk
Putative thymidine kinase.
       0.770
SUB0869
Putative 4-oxalocrotonate tautomerase.
  
    0.661
SUB0654
Similar to Granulicatella adiacens hypothetical protein GAD190 UniProt:Q7WYD7_9LACT (EMBL:AB100598) (190 aa) blastp scores: E()=2e-25. CDS contains a frameshift after codon 12. Frameshift occurs at a poly G pentamer.
  
     0.578
SUB0754
Conserved hypothetical protein.
  
     0.551
SUB1628
Putative membrane protein.
  
     0.537
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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