Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (327 aa)    
Predicted Functional Partners:
pyk
Putative pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.979
pdhB
Putative pyruvate dehydrogenase E1 component, beta subunit.
  
 0.969
SUB0825
NAD-dependent malic enzyme.
  
 0.968
pfl
Formate acetyltransferase.
   
 
 0.934
pdhA
Putative pyruvate dehydrogenase E1 component, alpha subunit.
  
 
 0.933
ppdK
Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family.
  
 
 0.932
pgi
Glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 0.921
SUB1584
Putative carboxylase subunit.
    
 0.917
SUB1803
Full length CDS is similar to similar to Azoarcus sp. (strain EbN1) fusion of 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase UniProt:Q5P607_AZOSE (EMBL:CR555306) (671 aa) fasta scores: E()=4.2e-35, 28.299% id in 682 aa. N-terminal region is similar to Homo sapiens (Human) short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor UniProt:HCDH_HUMAN (EMBL:HSAF1902) (314 aa) fasta scores: E()=3.3e-22, 37.687% id in 268 aa.
  
 0.917
SUB1529
Putative aminotransferase.
  
 0.910
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.