close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srtASortase A. (252 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.869
SUB0882
Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein.
       0.663
SUB0207
Putative surface-anchored protein.
     
 0.616
fruA
Putative fructan beta-fructosidase precursor.
     
 0.584
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
  
 0.573
SUB0241
Internal region is similar to Escherichia coli 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor CpdB UniProt:CN16_ECOLI (EMBL:ECCPDB) (647 aa) fasta scores: E()=5.6e-90, 46.809% id in 611 aa.
   
  
 0.557
fbpS
Fibronectin/fibrinogen-binding protein.
      
 0.555
scpA-2
C5A peptidase precursor.
   
  
 0.548
SUB1370
Putative zinc carboxypeptidase; Possible surface-anchored protein. CDS is orthologous to Streptococcal proteins which have a sortase-processing, cell wall-anchor motif (i.e. LPXTG), however the CDS lacks such a motif.
  
  
 0.547
sclB
Collagen-like surface-anchored protein.
     
 0.538
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
Server load: medium (52%) [HD]