Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
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[Homology]
Score
ciaRResponse regulator protein. (224 aa)    
Predicted Functional Partners:
ciaH
Sensor histidine kinase.
 
 0.999
htrA
Serine protease.
  
  
 0.981
SUB0191
Sensor histidine kinase.
 
 
 0.868
SUB0202
Sensor histidine kinase.
 
 
 0.864
SUB0916
Sensor histidine kinase.
 
 
 0.824
phoR
Similar to the C-terminal region of Bacillus subtilis alkaline phosphatase synthesis sensor protein PhoR UniProt:PHOR_BACSU (EMBL:AF008220) (579 aa) fasta scores: E()=2.8e-31, 36.164% id in 365 aa, and to the full length Streptococcus pneumoniae histidine kinase PnpS UniProt:Q9X4S9_STRPN (EMBL:AF118229) (422 aa) fasta scores: E()=2.3e-77, 57.494% id in 407 aa.
 
 
 0.823
csrS
Sensor histidine kinase.
 
 
 0.808
vicK
Sensor histidine kinase.
 
 0.761
pepN
Putative lysyl-aminopeptidase.
  
  
 0.703
phoU
Putative phosphate transport system protein; Plays a role in the regulation of phosphate uptake.
  
  
 0.660
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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