Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SUB1176MutT/NUDIX family protein. (151 aa)    
Predicted Functional Partners:
uvrB
UvrABC system protein B (UvrB protein); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits [...]
     
 0.480
SUB1177
Putative membrane protein.
       0.468
SUB0908
NADPH-dependent FMN reductase; C-terminus is similar to the C-terminal region of Shewanella oneidensis fumarate reductase flavoprotein subunit precursor UniProt:FRDA_SHEON (EMBL:AE015541) (596 aa) fasta scores: E()=7.7e-27, 34.972% id in 529 aa. N-terminus is similar to SUB1685, 50.794% identity (51.064% ungapped) in 189 aa overlap (1-189:1-188); and the N-terminal region of SUB1686, 50.877% identity (51.786% ungapped) in 228 aa overlap (1-224:1-228).
 
     0.411
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.