Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
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textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
SUB1364Major facilitator superfamily protein. (427 aa)    
Predicted Functional Partners:
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
  
 0.933
aroD-2
3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family.
 
     0.886
SUB1367
LysR family regulatory protein; Belongs to the LysR transcriptional regulatory family.
 
  
 0.839
SUB1366
Conserved hypothetical protein.
 
    0.757
SUB1365
Short chain dehydrogenase.
 
   
 0.707
aroD
3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family.
 
     0.670
SUB1363
Major facilitator superfamily protein.
 
    
0.663
SUB1360
NADH:flavin oxidoreductase / NADH oxidase family protein.
 
  
 0.532
SUB0908
NADPH-dependent FMN reductase; C-terminus is similar to the C-terminal region of Shewanella oneidensis fumarate reductase flavoprotein subunit precursor UniProt:FRDA_SHEON (EMBL:AE015541) (596 aa) fasta scores: E()=7.7e-27, 34.972% id in 529 aa. N-terminus is similar to SUB1685, 50.794% identity (51.064% ungapped) in 189 aa overlap (1-189:1-188); and the N-terminal region of SUB1686, 50.877% identity (51.786% ungapped) in 228 aa overlap (1-224:1-228).
 
   
 0.408
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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