Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SUB1736RNA pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (294 aa)    
Predicted Functional Partners:
SUB1735
Conserved hypothetical protein.
       0.835
SUB1734
Conserved hypothetical protein.
  
    0.679
rpmG-2
50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.
   
   0.678
pbp2A
Penicillin-binding protein 2a.
  
    0.659
SUB1732
Putative preprotein translocase SecE subunit; Belongs to the SecE/SEC61-gamma family.
       0.613
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
 
 
 0.600
SUB0273
Putative membrane protein (fragment); Probable gene remnant. Similar to the N-terminal regions of Streptococcus pyogenes (serotype M18) hypothetical protein spym18_2006. UniProt:Q8NZD2_STRP8 (EMBL:AE010104) (265 aa) fasta scores: E()=3.1e-05, 28.777% id in 139 aa, and Streptococcus pyogenes hypothetical protein spy1939. UniProt:Q99Y01_STRPY (EMBL:AE006617) (265 aa) fasta scores: E()=3.1e-05, 28.777% id in 139 aa. Missing C-terminal region contains transmembrane domain; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
 
 
 0.589
nusG
Transcription antitermination factor; Participates in transcription elongation, termination and antitermination.
     
 0.558
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
 
  
 0.556
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
 
   0.550
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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