nrdD protein (Streptococcus uberis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

nrdD

Anaerobic ribonucleoside-triphosphate reductase. (731 aa)

Predicted Functional Partners:

nrdG

0.964

SUB0937

0.915

SUB1683

0.915

ndk

0.909

pyrG

0.907

relA

0.902

SUB0852

0.900

pyk

0.900

folE

0.800

SUB1773

0.581

Your Current Organism:

Streptococcus uberis

NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SUB0852	SUB0937	SUB0852	SUB0937	Conserved hypothetical protein.	ATP-binding protein.	0.900
SUB0852	folE	SUB0852	SUB0813	Conserved hypothetical protein.	GTP cyclohydrolase I.	0.800
SUB0852	ndk	SUB0852	SUB1084	Conserved hypothetical protein.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.900
SUB0852	nrdD	SUB0852	SUB1772	Conserved hypothetical protein.	Anaerobic ribonucleoside-triphosphate reductase.	0.900
SUB0852	pyk	SUB0852	SUB1000	Conserved hypothetical protein.	Putative pyruvate kinase; Belongs to the pyruvate kinase family.	0.900
SUB0852	relA	SUB0852	SUB0242	Conserved hypothetical protein.	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.924
SUB0937	SUB0852	SUB0937	SUB0852	ATP-binding protein.	Conserved hypothetical protein.	0.900
SUB0937	SUB1683	SUB0937	SUB1683	ATP-binding protein.	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.915
SUB0937	folE	SUB0937	SUB0813	ATP-binding protein.	GTP cyclohydrolase I.	0.800
SUB0937	ndk	SUB0937	SUB1084	ATP-binding protein.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.909
SUB0937	nrdD	SUB0937	SUB1772	ATP-binding protein.	Anaerobic ribonucleoside-triphosphate reductase.	0.915
SUB0937	nrdG	SUB0937	SUB1768	ATP-binding protein.	Putative anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.	0.814
SUB0937	pyk	SUB0937	SUB1000	ATP-binding protein.	Putative pyruvate kinase; Belongs to the pyruvate kinase family.	0.900
SUB0937	pyrG	SUB0937	SUB0326	ATP-binding protein.	Putative CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.907
SUB0937	relA	SUB0937	SUB0242	ATP-binding protein.	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.901
SUB1683	SUB0937	SUB1683	SUB0937	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	ATP-binding protein.	0.915
SUB1683	ndk	SUB1683	SUB1084	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.928
SUB1683	nrdD	SUB1683	SUB1772	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Anaerobic ribonucleoside-triphosphate reductase.	0.915
SUB1773	nrdD	SUB1773	SUB1772	Putative membrane protein.	Anaerobic ribonucleoside-triphosphate reductase.	0.581
SUB1773	nrdG	SUB1773	SUB1768	Putative membrane protein.	Putative anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.	0.423