trsA protein (Streptococcus uberis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

trsA

tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (340 aa)

Predicted Functional Partners:

pheT

0.710

guaB

0.696

serS

0.593

metG

0.592

guaA

0.582

SUB0026

0.567

argS

0.561

pheS

0.491

lepA

0.485

lysS

0.483

Your Current Organism:

Streptococcus uberis

NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SUB0026	argS	SUB0026	SUB1789	Putative phosphoribosylformylglycinamidine synthase protein.	arginyl-tRNA synthetase.	0.594
SUB0026	guaA	SUB0026	SUB0891	Putative phosphoribosylformylglycinamidine synthase protein.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.981
SUB0026	guaB	SUB0026	SUB1862	Putative phosphoribosylformylglycinamidine synthase protein.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.920
SUB0026	lysS	SUB0026	SUB0592	Putative phosphoribosylformylglycinamidine synthase protein.	lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.571
SUB0026	metG	SUB0026	SUB0459	Putative phosphoribosylformylglycinamidine synthase protein.	methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.	0.819
SUB0026	pheT	SUB0026	SUB0680	Putative phosphoribosylformylglycinamidine synthase protein.	phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.	0.974
SUB0026	trsA	SUB0026	SUB1863	Putative phosphoribosylformylglycinamidine synthase protein.	tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.567
argS	SUB0026	SUB1789	SUB0026	arginyl-tRNA synthetase.	Putative phosphoribosylformylglycinamidine synthase protein.	0.594
argS	guaA	SUB1789	SUB0891	arginyl-tRNA synthetase.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.934
argS	lepA	SUB1789	SUB1082	arginyl-tRNA synthetase.	GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	0.589
argS	lysS	SUB1789	SUB0592	arginyl-tRNA synthetase.	lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.792
argS	metG	SUB1789	SUB0459	arginyl-tRNA synthetase.	methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.	0.881
argS	pheS	SUB1789	SUB0678	arginyl-tRNA synthetase.	phenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.	0.443
argS	pheT	SUB1789	SUB0680	arginyl-tRNA synthetase.	phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.	0.774
argS	serS	SUB1789	SUB1489	arginyl-tRNA synthetase.	seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).	0.595
argS	trsA	SUB1789	SUB1863	arginyl-tRNA synthetase.	tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.561
guaA	SUB0026	SUB0891	SUB0026	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Putative phosphoribosylformylglycinamidine synthase protein.	0.981
guaA	argS	SUB0891	SUB1789	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	arginyl-tRNA synthetase.	0.934
guaA	guaB	SUB0891	SUB1862	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.999
guaA	lepA	SUB0891	SUB1082	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	0.542