STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEP74321.1DNA gyrase subunit A gyrA. (829 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase B subunit gyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 0.999
EEP74320.1
DNA gyrase subunit B gyrB.
 0.999
EEP73949.1
Signal peptidase I; Truncated CDS; overlaps CDS with the same product name; Belongs to the peptidase S26 family.
  
  
 0.785
EEP71787.1
Hypothetical protein.
    
 
 0.714
EEP74271.1
Hypothetical protein.
    
 
 0.714
ftsZ
Cell division protein ftsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
 
 
 0.709
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
  
 0.679
EEP72560.1
Hypothetical protein.
  
  
 0.679
dnaK
Hsp70-like protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 
 0.672
pheT
phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.640
Your Current Organism:
Micromonospora sp. ATCC 39149
NCBI taxonomy Id: 219305
Other names: M. sp. ATCC 39149, Micromonospora carbonacea var. africana, Micromonospora sp. NRRL 15099
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