node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A7J50_0559 | A7J50_3440 | A7J50_0559 | A7J50_3440 | Curved DNA-binding protein; Pfam:pfam00226 DnaJ domain. | Clp protease ClpX; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | 0.625 |
A7J50_0559 | clpB | A7J50_0559 | A7J50_0787 | Curved DNA-binding protein; Pfam:pfam00226 DnaJ domain. | Chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.625 |
A7J50_0559 | dnaK | A7J50_0559 | A7J50_5015 | Curved DNA-binding protein; Pfam:pfam00226 DnaJ domain. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.964 |
A7J50_0559 | groL | A7J50_0559 | A7J50_4756 | Curved DNA-binding protein; Pfam:pfam00226 DnaJ domain. | Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.795 |
A7J50_0559 | groS | A7J50_0559 | A7J50_4757 | Curved DNA-binding protein; Pfam:pfam00226 DnaJ domain. | Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.713 |
A7J50_0559 | grpE | A7J50_0559 | A7J50_5016 | Curved DNA-binding protein; Pfam:pfam00226 DnaJ domain. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.950 |
A7J50_0559 | htpG | A7J50_0559 | A7J50_1964 | Curved DNA-binding protein; Pfam:pfam00226 DnaJ domain. | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | 0.942 |
A7J50_3440 | A7J50_0559 | A7J50_3440 | A7J50_0559 | Clp protease ClpX; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Curved DNA-binding protein; Pfam:pfam00226 DnaJ domain. | 0.625 |
A7J50_3440 | dnaJ | A7J50_3440 | A7J50_5014 | Clp protease ClpX; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.621 |
A7J50_3440 | dnaK | A7J50_3440 | A7J50_5015 | Clp protease ClpX; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.766 |
A7J50_3440 | groL | A7J50_3440 | A7J50_4756 | Clp protease ClpX; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.489 |
A7J50_3440 | groS | A7J50_3440 | A7J50_4757 | Clp protease ClpX; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.547 |
A7J50_3440 | grpE | A7J50_3440 | A7J50_5016 | Clp protease ClpX; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.700 |
A7J50_3440 | htpG | A7J50_3440 | A7J50_1964 | Clp protease ClpX; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family. | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | 0.596 |
A7J50_4835 | dnaK | A7J50_4835 | A7J50_5015 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.826 |
A7J50_4835 | hscB | A7J50_4835 | A7J50_4833 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.997 |
clpB | A7J50_0559 | A7J50_0787 | A7J50_0559 | Chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Curved DNA-binding protein; Pfam:pfam00226 DnaJ domain. | 0.625 |
clpB | dnaJ | A7J50_0787 | A7J50_5014 | Chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.639 |
clpB | dnaK | A7J50_0787 | A7J50_5015 | Chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.799 |
clpB | groL | A7J50_0787 | A7J50_4756 | Chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.547 |