STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A7J50_5729Bifunctional (P)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (701 aa)    
Predicted Functional Partners:
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.953
A7J50_5641
Exopolyphosphatase; Pfam:pfam02541 Ppx/GppA phosphatase family; Belongs to the GppA/Ppx family.
  
 
 0.925
A7J50_4186
Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain.
  
 
 0.923
A7J50_1928
Pfam:pfam00224 Pyruvate kinase, barrel domain; Belongs to the pyruvate kinase family.
  
 
 0.916
A7J50_4718
Pfam:pfam00224 Pyruvate kinase, barrel domain; Belongs to the pyruvate kinase family.
  
 
 0.916
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.916
A7J50_4187
(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
  
 
0.915
A7J50_1758
Hypothetical protein; Pfam:pfam04607 Region found in RelA / SpoT proteins.
    
 0.913
A7J50_2322
Hypothetical protein; Pfam:pfam04607 Region found in RelA / SpoT proteins.
    
 0.913
A7J50_4491
Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
 0.911
Your Current Organism:
Pseudomonas antarctica
NCBI taxonomy Id: 219572
Other names: CCUG 49625, DSM 15318, LMG 22709, LMG:22709, MTCC 4992, Pseudomonas antarctica Reddy et al. 2004, strain CMS 35
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.