node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GCA_001571405_00308 | aroE | GCA_001571405_00308 | GCA_001571405_02047 | Unannotated protein. | Unannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.950 |
GCA_001571405_00308 | cobD | GCA_001571405_00308 | GCA_001571405_01685 | Unannotated protein. | Unannotated protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.993 |
GCA_001571405_00308 | cobQ | GCA_001571405_00308 | GCA_001571405_01056 | Unannotated protein. | Unannotated protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.974 |
GCA_001571405_00308 | hisA | GCA_001571405_00308 | GCA_001571405_00520 | Unannotated protein. | Unannotated protein. | 0.930 |
GCA_001571405_00308 | hisB | GCA_001571405_00308 | GCA_001571405_00519 | Unannotated protein. | Unannotated protein. | 0.995 |
GCA_001571405_00308 | hisD | GCA_001571405_00308 | GCA_001571405_01161 | Unannotated protein. | Unannotated protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.992 |
GCA_001571405_00308 | hisF | GCA_001571405_00308 | GCA_001571405_01264 | Unannotated protein. | Unannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.959 |
GCA_001571405_00308 | hisG | GCA_001571405_00308 | GCA_001571405_00521 | Unannotated protein. | Unannotated protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.940 |
GCA_001571405_00308 | hisH | GCA_001571405_00308 | GCA_001571405_00175 | Unannotated protein. | Unannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.959 |
GCA_001571405_00308 | hisI | GCA_001571405_00308 | GCA_001571405_01050 | Unannotated protein. | Unannotated protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.944 |
aroE | GCA_001571405_00308 | GCA_001571405_02047 | GCA_001571405_00308 | Unannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Unannotated protein. | 0.950 |
aroE | hisA | GCA_001571405_02047 | GCA_001571405_00520 | Unannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Unannotated protein. | 0.726 |
aroE | hisD | GCA_001571405_02047 | GCA_001571405_01161 | Unannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Unannotated protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.819 |
aroE | hisF | GCA_001571405_02047 | GCA_001571405_01264 | Unannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Unannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.654 |
aroE | hisG | GCA_001571405_02047 | GCA_001571405_00521 | Unannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Unannotated protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.619 |
aroE | hisI | GCA_001571405_02047 | GCA_001571405_01050 | Unannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Unannotated protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.644 |
cobD | GCA_001571405_00308 | GCA_001571405_01685 | GCA_001571405_00308 | Unannotated protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Unannotated protein. | 0.993 |
cobD | cobQ | GCA_001571405_01685 | GCA_001571405_01056 | Unannotated protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Unannotated protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.998 |
cobQ | GCA_001571405_00308 | GCA_001571405_01056 | GCA_001571405_00308 | Unannotated protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Unannotated protein. | 0.974 |
cobQ | cobD | GCA_001571405_01056 | GCA_001571405_01685 | Unannotated protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Unannotated protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.998 |