STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (336 aa)    
Predicted Functional Partners:
GCA_001571405_00469
Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.999
guaB
Unannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.998
GCA_001571405_00543
Unannotated protein; Belongs to the carbohydrate kinase PfkB family.
  
 0.997
GCA_001571405_02251
Unannotated protein.
  
 0.997
pyrB
Unannotated protein.
  
 
 0.990
argG
Unannotated protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.987
GCA_001571405_00468
Unannotated protein.
  
 
 0.986
surE
Unannotated protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.981
pyrI
Unannotated protein; Involved in allosteric regulation of aspartate carbamoyltransferase.
    
 0.980
GCA_001571405_00202
Unannotated protein.
  
 
 0.979
Your Current Organism:
Methanoculleus thermophilus
NCBI taxonomy Id: 2200
Other names: ATCC 33837, DSM 2373, M. thermophilus, Methaniculleus thermophilicus, Methanoculleus thermophilicum, Methanoculleus thermophilicus, Methanogenium frittonii, Methanogenium thermophilicum, Methanogenium thermophilum, OCM 174, strain CR-1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.