STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GCA_001571405_02140Unannotated protein; Belongs to the peptidase S16 family. (662 aa)    
Predicted Functional Partners:
GCA_001571405_02139
Unannotated protein.
     
 0.844
GCA_001571405_02138
Unannotated protein.
       0.839
grpE
Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]
  
  
 0.780
GCA_001571405_02137
Unannotated protein.
       0.775
dnaK
Unannotated protein; Acts as a chaperone.
 
  
 0.759
GCA_001571405_02145
Unannotated protein; Belongs to the TCP-1 chaperonin family.
  
 
 0.748
GCA_001571405_02144
Unannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
     0.714
GCA_001571405_02060
Unannotated protein.
 
  
 0.697
GCA_001571405_02143
Unannotated protein.
 
     0.690
dnaJ
Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]
 
  
 0.679
Your Current Organism:
Methanoculleus thermophilus
NCBI taxonomy Id: 2200
Other names: ATCC 33837, DSM 2373, M. thermophilus, Methaniculleus thermophilicus, Methanoculleus thermophilicum, Methanoculleus thermophilicus, Methanogenium frittonii, Methanogenium thermophilicum, Methanogenium thermophilum, OCM 174, strain CR-1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.