STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
btuFCobalamin periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. (266 aa)    
Predicted Functional Partners:
STY1770
Vitamin B12 transport system permease; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.
 
 
 0.998
STY1768
Vitamin B12 ABC transport ATP-binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
  
 
 0.985
STY3744
Vitamin B12 receptor protein; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
 
  
 0.899
mtn
MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...]
  
  
 0.880
STY0802
ABC transporter permease (FecCD_family); Similar to Corynebacterium diphtheriae HmuU hmuU TR:Q9XD88 (EMBL:AF109162) (350 aa) fasta scores: E(): 0, 37.0% id in 332 aa, and to Yersinia pestis hemin transport system permease protein HmuU hmuU SW:HMUU_YERPE (Q56992) (334 aa) fasta scores: E(): 0, 36.8% id in 323 aa; Fasta hit to FECD_ECOLI (318 aa), 32% identity in 324 aa overlap; Fasta hit to BTUC_ECOLI (326 aa), 33% identity in 332 aa overlap; Fasta hit to FECC_ECOLI (332 aa), 34% identity in 335 aa overlap; Fasta hit to FEPG_ECOLI (330 aa), 32% identity in 339 aa overlap; Paralogue of E [...]
 
 
 0.864
STY0636
Ferric enterobactin transport protein FepD; Fasta hit to FECD_ECOLI (318 aa), 37% identity in 317 aa overlap; Fasta hit to BTUC_ECOLI (326 aa), 39% identity in 318 aa overlap; Fasta hit to FECC_ECOLI (332 aa), 38% identity in 330 aa overlap; Fasta hit to FEPG_ECOLI (330 aa), 36% identity in 331 aa overlap; Orthologue of E. coli fepD (FEPD_ECOLI); Fasta hit to FEPD_ECOLI (334 aa), 89% identity in 333 aa overlap; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
 
 0.851
STY0221
Ferrichrome transport protein FhuB precursor; Orthologue of E. coli fhuB (FHUB_ECOLI); Fasta hit to FHUB_ECOLI (660 aa), 90% identity in 652 aa overlap; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
 
 0.820
STY0219
Ferrichrome transport ATP-binding protein FhuC; Fasta hit to FEPC_ECOLI (271 aa), 44% identity in 237 aa overlap; Fasta hit to FECE_ECOLI (255 aa), 44% identity in 239 aa overlap; Fasta hit to LIVF_ECOLI (237 aa), 30% identity in 225 aa overlap; Fasta hit to PHNK_ECOLI (252 aa), 30% identity in 217 aa overlap; Fasta hit to HISP_ECOLI (257 aa), 32% identity in 224 aa overlap; Fasta hit to BTUD_ECOLI (249 aa), 35% identity in 232 aa overlap; Fasta hit to PHNL_ECOLI (226 aa), 33% identity in 216 aa overlap; Fasta hit to PHNC_ECOLI (262 aa), 32% identity in 232 aa overlap; Fasta hit to NIK [...]
 
 
 0.762
STY0634
Ferric enterobactin transport ATP-binding protein FepC; Fasta hit to SSUB_ECOLI (255 aa), 33% identity in 225 aa overlap; Fasta hit to FHUC_ECOLI (265 aa), 45% identity in 237 aa overlap; Fasta hit to FECE_ECOLI (255 aa), 49% identity in 250 aa overlap; Fasta hit to HISP_ECOLI (257 aa), 31% identity in 229 aa overlap; Fasta hit to PHNC_ECOLI (262 aa), 30% identity in 246 aa overlap; Fasta hit to YECC_ECOLI (250 aa), 31% identity in 225 aa overlap; Fasta hit to YRBF_ECOLI (269 aa), 30% identity in 267 aa overlap; Fasta hit to GLNQ_ECOLI (240 aa), 33% identity in 220 aa overlap; Fasta hi [...]
 
 
 0.759
STY0803
Similar to Bacillus subtilis ferrichrome transport ATP-binding protein FhuC fhuC SW:FHUC_BACSU (P49938) (269 aa) fasta scores: E(): 6.7e-25, 35.7% id in 244 aa, and to Erwinia chrysanthemi achromobactin transport ATP-binding protein CbrD cbrD SW:CBRD_ERWCH (Q47087) (273 aa) fasta scores: E(): 2.9e-24, 35.7% id in 244 aa, and to Escherichia coli ferric enterobactin transport ATP-binding protein FepC fepC SW:FEPC_ECOLI (P23878; P75724; P77096) (271 aa) fasta scores: E(): 3e-22, 34.2% id in 240 aa; Fasta hit to YCFV_ECOLI (233 aa), 31% identity in 227 aa overlap; Fasta hit to ZNUC_ECOLI ( [...]
 
 
 0.721
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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