STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
STY0274Putative ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)    
Predicted Functional Partners:
STY0273
Putative ABC transporter permease protein; Part of the binding-protein-dependent transport system for D- methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity).
 
 0.999
STY0272
Putative lipoprotein precursor; This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system.
 
 0.997
sfbC
Similar to Salmonella enteritidis integral membrane protein sfbC TR:Q9S4Y9 (EMBL:AF102556) (202 aa) fasta scores: E(): 0, 99.5% id in 202 aa, and to Helicobacter pylori ABC transporter, permease protein hp1577 TR:O26097 (EMBL:AE000655) (215 aa) fasta scores: E(): 7.8e-31, 44.7% id in 208 aa; Paralogue of E. coli yaeE (YAEE_ECOLI); Fasta hit to YAEE_ECOLI (217 aa), 45% identity in 203 aa overlap.
 
 0.991
sfbA
Lipoprotein; Similar to Salmonella enteritidis lipoprotein sfbA TR:Q9S4Z1 (EMBL:AF102556) (276 aa) fasta scores: E(): 0, 99.3% id in 276 aa, and to Escherichia coli putative lipoprotein YaeC precursor yaeC SW:YAEC_ECOLI (P28635) (271 aa) fasta scores: E(): 1.1e-20, 37.6% id in 250 aa, and to Pasteurella haemolytica outer membrane lipoprotein 3 precursor plpC SW:PLPC_PASHA (Q08870; Q07365) (263 aa) fasta scores: E(): 2.6e-19, 37.0% id in 243 aa. Possibly a binding protein for the adjacent ABC-transporter; Fasta hit to NLPA_ECOLI (272 aa), 33% identity in 277 aa overlap; Paralogue of E. [...]
 
 0.989
sfbB
ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
  
  
 
0.906
STY0504
Putative ABC transporter ATP-binding membrane protein; Similar to Escherichia coli multidrug resistance-like ATP-binding protein mdlb mdlb or mdL SW:MDLB_ECOLI (P75706; P30751; P77117) (593 aa) fasta scores: E(): 0, 87.7% id in 593 aa, and to many ABC transporters e.g. Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein rv1272c rv1272c or mtcy50.10 SW:YC72_MYCTU (Q11047) (631 aa) fasta scores: E(): 0, 35.0% id in 523 aa, and to Rattus norvegicus tap-like ABC transporter tapL TR:Q9QYJ4 (EMBL:AB027520) (762 aa) fasta scores: E(): 0, 33.2% id in 585 aa; Orthologue [...]
 
     
0.721
mdlA
Putative ABC transporter ATP-binding membrane protein; Similar to Escherichia coli multidrug resistance-like ATP-binding protein mdla mdla or mdL SW:MDLA_ECOLI (P77265; P30751) (590 aa) fasta scores: E(): 0, 89.0% id in 590 aa, and to many ABC transporters e.g. Bacillus subtilis hypothetical 65.1 kDa protein yheI TR:O07550 (EMBL:Y14080) (585 aa) fasta scores: E(): 0, 39.8% id in 575 aa, and to Thermotoga maritima ABC transporter, ATP-binding protein tm1256 TR:Q9X0Y3 (EMBL:AE001781) (577 aa) fasta scores: E(): 0, 33.3% id in 567 aa; Orthologue of E. coli mdlA (MDLA_ECOLI); Fasta hit to [...]
 
     
0.659
metA
Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
  
    0.585
STY0275
Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position in vitro. Also catalyzes the dephosphorylation of D-glycero-alpha-D-manno-heptose 1,7- bisphosphate and 2-deoxy-D-manno-2-octoulosonate-8-phosphate in vitro. Belongs to the GmhB family.
       0.531
STY0876
Transcriptional regulator (iron dependant repressor family); In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity). Belongs to the DtxR/MntR family.
    
   0.519
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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