STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY0275Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position in vitro. Also catalyzes the dephosphorylation of D-glycero-alpha-D-manno-heptose 1,7- bisphosphate and 2-deoxy-D-manno-2-octoulosonate-8-phosphate in vitro. Belongs to the GmhB family. (188 aa)    
Predicted Functional Partners:
rfaE
ADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
  
 0.996
STY0355
Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily.
  
 0.992
waaF
Similar to Salmonella typhimurium ADP-heptose-LPS heptosyltransferase II rfaF or waaF SW:RFAF_SALTY (P37421) (348 aa) fasta scores: E(): 0, 99.1% id in 348 aa, and to Escherichia coli ADP-heptose-LPS heptosyltransferase II rfaF or waaF SW:RFAF_ECOLI (P37692) (348 aa) fasta scores: E(): 0, 92.2% id in 346 aa.
   
 0.963
STY3449
Probable phosphoheptose isomerase; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily.
  
 0.953
rfaD
ADP-L-Glycero-D-mannoheptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
 
  
 0.931
STY2287
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; Similar to Salmonella typhimurium histidine biosynthesis bifunctional protein HisI [includes: phosphoribosyl-AMP cyclohydrolase hisI SW:HIS2_SALTY (P10367) (203 aa) fasta scores: E(): 0, 97.5% id in 203 aa; Orthologue of E. coli hisI (HIS2_ECOLI); Fasta hit to HIS2_ECOLI (203 aa), 91% identity in 203 aa overlap; In the C-terminal section; belongs to the PRA-PH family.
  
  
 0.922
waaC
Similar to Salmonella typhimurium lipopolysaccharide heptosyltransferase-1 rfaC or waaC SW:RFAC_SALTY (P26469) (317 aa) fasta scores: E(): 0, 98.7% id in 317 aa, and to Escherichia coli lipopolysaccharide heptosyltransferase-1 rfaC or waaC or rfa-2 SW:RFAC_ECOLI (P24173) (319 aa) fasta scores: E(): 0, 84.2% id in 316 aa.
 
   
 0.790
waaQ
Similar to Salmonella typhimurium lipopolysaccharide core biosynthesis protein rfaq waaQ TR:O68270 (EMBL:AF026386) (344 aa) fasta scores: E(): 0, 99.4% id in 344 aa.
 
   
 0.709
STY2284
Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
  
  
 0.588
STY2281
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
  
 0.551
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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