STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
STY0362Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa)    
Predicted Functional Partners:
STY2751
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 0.988
deoD
Similar to Escherichia coli purine nucleoside phosphorylase deod or puP SW:DEOD_ECOLI (P09743) (238 aa) fasta scores: E(): 0, 97.1% id in 238 aa.
    
 0.964
STY0192
Hypoxanthine phosphoribosyltransferase; Orthologue of E. coli hpt (HPRT_ECOLI); Fasta hit to HPRT_ECOLI (182 aa), 95% identity in 171 aa overlap; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
 0.955
STY2752
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.949
STY4052
5'guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.948
STY0527
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.946
STY0535
Inosine-guanosine kinase; Orthologue of E. coli gsk (INGK_ECOLI); Fasta hit to INGK_ECOLI (434 aa), 94% identity in 434 aa overlap.
   
 0.944
STY2658
Xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 
 0.925
STY2675
Putative amidotransferase; Similar, in part, to Salmonella typhimurium LT2 hypothetical protein yfeJ SW:YFEJ_SALTY (P40194) (170 aa) fasta scores: E(): 0, 89.0% id in 155 aa. The similarity ends due to a deletion in S. typhimurium with respect to S. typhi. Similar to Zymomonas mobilis hypothetical protein TR:Q9RQD2 (EMBL:AF117351) (251 aa) fasta scores: E(): 0, 53.1% id in 239 aa and Pseudomonas aeruginosa probable glutamine amidotransferase PA0531 TR:AAG03920 (EMBL:AE004489) (238 aa) fasta scores: E(): 2.1e-16, 31.9% id in 238 aa.
  
 
 0.925
STY0163
GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
  
 
 0.921
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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