STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sfbBABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (338 aa)    
Predicted Functional Partners:
sfbA
Lipoprotein; Similar to Salmonella enteritidis lipoprotein sfbA TR:Q9S4Z1 (EMBL:AF102556) (276 aa) fasta scores: E(): 0, 99.3% id in 276 aa, and to Escherichia coli putative lipoprotein YaeC precursor yaeC SW:YAEC_ECOLI (P28635) (271 aa) fasta scores: E(): 1.1e-20, 37.6% id in 250 aa, and to Pasteurella haemolytica outer membrane lipoprotein 3 precursor plpC SW:PLPC_PASHA (Q08870; Q07365) (263 aa) fasta scores: E(): 2.6e-19, 37.0% id in 243 aa. Possibly a binding protein for the adjacent ABC-transporter; Fasta hit to NLPA_ECOLI (272 aa), 33% identity in 277 aa overlap; Paralogue of E. [...]
 
 0.999
sfbC
Similar to Salmonella enteritidis integral membrane protein sfbC TR:Q9S4Y9 (EMBL:AF102556) (202 aa) fasta scores: E(): 0, 99.5% id in 202 aa, and to Helicobacter pylori ABC transporter, permease protein hp1577 TR:O26097 (EMBL:AE000655) (215 aa) fasta scores: E(): 7.8e-31, 44.7% id in 208 aa; Paralogue of E. coli yaeE (YAEE_ECOLI); Fasta hit to YAEE_ECOLI (217 aa), 45% identity in 203 aa overlap.
 
 0.999
STY0273
Putative ABC transporter permease protein; Part of the binding-protein-dependent transport system for D- methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity).
 
 0.993
STY0272
Putative lipoprotein precursor; This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system.
 
 0.989
STY0274
Putative ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
  
  
 
0.906
STY0548
Putative ABC transporter ATP-binding protein; Fasta hit to ARTP_ECOLI (242 aa), 31% identity in 216 aa overlap; Fasta hit to YCFV_ECOLI (233 aa), 33% identity in 192 aa overlap; Fasta hit to SSUB_ECOLI (255 aa), 33% identity in 204 aa overlap; Fasta hit to ZNUC_ECOLI (251 aa), 31% identity in 210 aa overlap; Fasta hit to FTSE_ECOLI (222 aa), 35% identity in 204 aa overlap; Fasta hit to YECC_ECOLI (250 aa), 32% identity in 216 aa overlap; Fasta hit to P76909 (246 aa), 33% identity in 215 aa overlap; Fasta hit to YRBF_ECOLI (269 aa), 32% identity in 227 aa overlap; Fasta hit to YABJ_ECOL [...]
 
    
0.721
metA
Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
  
    0.525
STY3761
5,10 methylenetetrahydrofolate reductase; Orthologue of E. coli metF (METF_ECOLI); Fasta hit to METF_ECOLI (296 aa), 96% identity in 296 aa overlap; Belongs to the methylenetetrahydrofolate reductase family.
   
  
 0.519
STY3243
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
  
 0.483
STY0876
Transcriptional regulator (iron dependant repressor family); In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity). Belongs to the DtxR/MntR family.
    
 
 0.471
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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