node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STY0162 | STY0771 | gene:17584201 | gene:17584777 | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.595 |
STY0162 | STY1669 | gene:17584201 | gene:17585604 | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.427 |
STY0162 | STY3881 | gene:17584201 | gene:17587738 | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.738 |
STY0752 | STY0753 | gene:17584761 | gene:17584762 | Conserved hypothetical protein; Orthologue of E. coli YBGJ_ECOLI; Fasta hit to YBGJ_ECOLI (218 aa), 86% identity in 218 aa overlap. | Conserved hypothetical protein; Orthologue of E. coli YBGK_ECOLI; Fasta hit to YBGK_ECOLI (310 aa), 85% identity in 310 aa overlap. | 0.999 |
STY0752 | STY0754 | gene:17584761 | gene:17584763 | Conserved hypothetical protein; Orthologue of E. coli YBGJ_ECOLI; Fasta hit to YBGJ_ECOLI (218 aa), 86% identity in 218 aa overlap. | Conserved hypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. | 0.999 |
STY0752 | STY0771 | gene:17584761 | gene:17584777 | Conserved hypothetical protein; Orthologue of E. coli YBGJ_ECOLI; Fasta hit to YBGJ_ECOLI (218 aa), 86% identity in 218 aa overlap. | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.558 |
STY0753 | STY0752 | gene:17584762 | gene:17584761 | Conserved hypothetical protein; Orthologue of E. coli YBGK_ECOLI; Fasta hit to YBGK_ECOLI (310 aa), 85% identity in 310 aa overlap. | Conserved hypothetical protein; Orthologue of E. coli YBGJ_ECOLI; Fasta hit to YBGJ_ECOLI (218 aa), 86% identity in 218 aa overlap. | 0.999 |
STY0753 | STY0754 | gene:17584762 | gene:17584763 | Conserved hypothetical protein; Orthologue of E. coli YBGK_ECOLI; Fasta hit to YBGK_ECOLI (310 aa), 85% identity in 310 aa overlap. | Conserved hypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. | 0.999 |
STY0753 | STY0771 | gene:17584762 | gene:17584777 | Conserved hypothetical protein; Orthologue of E. coli YBGK_ECOLI; Fasta hit to YBGK_ECOLI (310 aa), 85% identity in 310 aa overlap. | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.571 |
STY0754 | STY0752 | gene:17584763 | gene:17584761 | Conserved hypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. | Conserved hypothetical protein; Orthologue of E. coli YBGJ_ECOLI; Fasta hit to YBGJ_ECOLI (218 aa), 86% identity in 218 aa overlap. | 0.999 |
STY0754 | STY0753 | gene:17584763 | gene:17584762 | Conserved hypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. | Conserved hypothetical protein; Orthologue of E. coli YBGK_ECOLI; Fasta hit to YBGK_ECOLI (310 aa), 85% identity in 310 aa overlap. | 0.999 |
STY0754 | STY0771 | gene:17584763 | gene:17584777 | Conserved hypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.731 |
STY0770 | STY0771 | gene:17584776 | gene:17584777 | Hypothetical protein; No database matches. | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.666 |
STY0771 | STY0162 | gene:17584777 | gene:17584201 | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.595 |
STY0771 | STY0752 | gene:17584777 | gene:17584761 | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Conserved hypothetical protein; Orthologue of E. coli YBGJ_ECOLI; Fasta hit to YBGJ_ECOLI (218 aa), 86% identity in 218 aa overlap. | 0.558 |
STY0771 | STY0753 | gene:17584777 | gene:17584762 | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Conserved hypothetical protein; Orthologue of E. coli YBGK_ECOLI; Fasta hit to YBGK_ECOLI (310 aa), 85% identity in 310 aa overlap. | 0.571 |
STY0771 | STY0754 | gene:17584777 | gene:17584763 | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Conserved hypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. | 0.731 |
STY0771 | STY0770 | gene:17584777 | gene:17584776 | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Hypothetical protein; No database matches. | 0.666 |
STY0771 | STY1669 | gene:17584777 | gene:17585604 | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.520 |
STY0771 | STY1804 | gene:17584777 | gene:17585737 | Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Conserved hypothetical protein; Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity). | 0.505 |