STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
STY0771Endonuclease VIII, DNA N-glycosylase with an AP lyase activity; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (263 aa)    
Predicted Functional Partners:
STY3881
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.936
STY0754
Conserved hypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
    
 0.731
STY0770
Hypothetical protein; No database matches.
       0.666
STY0162
Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.595
STY0753
Conserved hypothetical protein; Orthologue of E. coli YBGK_ECOLI; Fasta hit to YBGK_ECOLI (310 aa), 85% identity in 310 aa overlap.
    
 0.571
STY0752
Conserved hypothetical protein; Orthologue of E. coli YBGJ_ECOLI; Fasta hit to YBGJ_ECOLI (218 aa), 86% identity in 218 aa overlap.
    
 0.558
STY1669
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
   
  
 0.520
STY1804
Conserved hypothetical protein; Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity).
 
  
 0.505
STY3111
5'-3' exonuclease; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
  
  
 0.496
STY4849
Helicase related protein; Possible helicase. Similar to Deinococcus radiodurans RNA helicase, putative DRB0135 TR:Q9RZJ2 (EMBL:AE001826) (1706 aa) fasta scores: E(): 5.6e-16, 24.4% id in 810 aa. C-terminal region of the protein is similar to the C-terminal region of Escherichia coli McrD protein SW:MCRD_ECOLI (P27301) (409 aa) fasta scores: E(): 0, 62.3% id in 273 aa. N-terminal region of the protein is similar to the N-terminal region of mcrD and to the C-terminus of Escherichia coli hypothetical 58.2 kDa protein in iadA-mcrD intergenic region YjiV SW:YJIV_ECOLI (P39393; P39392) (513 [...]
  
  
 0.440
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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