STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (561 aa)    
Predicted Functional Partners:
hutH
Similar to Pseudomonas putida histidine ammonia-lyase SW:HUTH_PSEPU (P21310) (509 aa) fasta scores: E(): 0, 77.4% id in 500 aa, and to Rhizobium meliloti histidine ammonia-lyase SW:HUTH_RHIME () (511 aa) fasta scores: E(): 0, 52.6% id in 498 aa; Belongs to the PAL/histidase family.
 
 0.999
hutI
Imidazolonepropionase; Similar to Yersinia pestis imidazolonepropionase hutI SW:HUTI_YERPE (Q9ZC74) (406 aa) fasta scores: E(): 0, 50.0% id in 400 aa, and to Rhizobium meliloti imidazolonepropionase hutI SW:HUTI_RHIME (O31196) (369 aa) fasta scores: E(): 0, 51.8% id in 340 aa; Belongs to the metallo-dependent hydrolases superfamily. HutI family.
 
 
 0.998
hutC
Similar to Klebsiella aerogenes histidine utilization repressor hutC SW:HUTC_KLEAE (P12380) (241 aa) fasta scores: E(): 0, 78.8% id in 241 aa, and to Pseudomonas putida histidine utilization repressor hutC SW:HUTC_PSEPU (P22773) (248 aa) fasta scores: E(): 0, 63.5% id in 230 aa.
 
  
 0.883
hutG
Formiminoglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family.
 
  
 0.742
STY0266
Copper homeostasis protein CutF precursor (lipoprotein nlpE); Orthologue of E. coli CutF (CUTF_ECOLI); Fasta hit to CUTF_ECOLI (236 aa), 76% identity in 232 aa overlap. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
      
 0.700
yfbB
Conserved hypothetical protein; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
      
 0.700
STY4211
Putative PTR2 family transport protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily.
      
 0.700
ybaO
Similar to Escherichia coli hypothetical transcriptional regulator in mdl-cof intergenic region ybaO SW:YBAO_ECOLI (P54986; P71209; P77575) (152 aa) fasta scores: E(): 0, 95.4% id in 152 aa, and to Zymomonas mobilis glutamate uptake regulatory protein grP SW:GRP_ZYMMO (P74996) (164 aa) fasta scores: E(): 9.7e-26, 44.0% id in 150 aa, and to Pseudomonas putida bkd operon transcriptional regulator bkdR SW:BKDR_PSEPU (P42179) (161 aa) fasta scores: E(): 1.2e-17, 35.3% id in 153 aa; Fasta hit to LRP_ECOLI (163 aa), 34% identity in 151 aa overlap; Orthologue of E. coli YBAO_ECOLI; Fasta hit [...]
     
 0.667
pncA
Similar to Escherichia coli pyrazinamidase/nicotinamidase [includes: pyrazinamidase pncA or nam SW:PNCA_ECOLI (P21369; P76229; P76910) (213 aa) fasta scores: E(): 0, 80.8% id in 213 aa.
      
 0.587
oadA
Oxaloacetate decarboxylase alpha chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
      
 0.562
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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