STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY0995KicA protein; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF. (225 aa)    
Predicted Functional Partners:
STY0994
Killing factor KicB; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.
 
 
 0.999
mukB
Cell division protein; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division; Belongs to the SMC family. MukB subfamily.
 
 
 0.998
STY1090
Conserved hypothetical protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
  
 
 
 0.914
smtA
SmtA protein; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
     
 0.854
STY1031
Putative bacteriophage protein; No significant database matches.
      
 0.812
celB
PTS system, cellobiose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
      
 0.811
STY4453
Putative integral membrane protein; Similar to the C-terminus of Salmonella typhimurium hypothetical protein SPI4_A TR:O85311 (EMBL:AF060869) (524 aa) fasta scores: E(): 0, 95.4% id in 307 aa. Also similar to Salmonella typhimurium hypothetical protein SPI4_B TR:O85312 (EMBL:AF060869) (121 aa) fasta scores: E(): 0, 98.3% id in 121 aa. Contains multiple possible membrane spanning hydrophobic domains including a possible N-terminal signal sequence.
  
 
 0.734
STY1311
Similar to Haemophilus influenzae hypothetical protein Hi1450 hi1450 SW:YCIU_HAEIN (P44199) (107 aa) fasta scores: E(): 3.1e-19, 46.1% id in 102 aa; Orthologue of E. coli YCIU_ECOLI; Fasta hit to YCIU_ECOLI (109 aa), 94% identity in 109 aa overlap; Belongs to the UPF0263 family.
  
     0.723
STY0487
Putative lipoprotein; Orthologue of E. coli yajG (YAJG_ECOLI); Fasta hit to YAJG_ECOLI (192 aa), 90% identity in 192 aa overlap.
  
     0.721
trpR
Probable trp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).
  
     0.710
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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