STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hpaC4-hydroxyphenylacetate 3-monooxygenase coupling protein; Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the large HpaB component or to other electron acceptors such as cytochrome c and Fe(3+) ion (By similarity); Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily. (170 aa)    
Predicted Functional Partners:
hpaB
Similar to Escherichia coli 4-hydroxyphenylacetate 3-monooxygenase hpaB TR:Q57160 (EMBL:Z37980) fasta scores: E(): 0, 95.6% id in 435 aa. Note discrepency in position of translational start site.
 
 
 0.998
STY3580
Flavin reductase; Orthologue of E. coli ubiB (UBIB_ECOLI); Fasta hit to UBIB_ECOLI (232 aa), 91% identity in 232 aa overlap.
  
 
  0.914
STY0900
Similar to Escherichia coli hypothetical protein YbjI SW:YBJI_ECOLI (P75809) (271 aa) fasta scores: E(): 0, 83.7% id in 270 aa, and to Bacillus subtilis hypothetical protein YitU TR:P70947 (EMBL:Z79580) (270 aa) fasta scores: E(): 5.7e-10, 25.6% id in 270 aa.
  
  
  0.911
ribF
Similar to Escherichia coli riboflavin biosynthesis protein RibF [includes: riboflavin kinase; FMN adenylyltransferase] RIBF SW:RIBF_ECOLI (P08391; P75621) fasta scores: E(): 0, 90.0% id in 309 aa, and to Pseudomonas fluorescens riboflavin biosynthesis protein ribf [includes: riboflavin kinase; FMN adenylyltransferase] RIBF SW:RIBF_PSEFL (P22990) fasta scores: E(): 0, 52.6% id in 304 aa; Orthologue of E. coli yaaC (RIBF_ECOLI); Fasta hit to RIBF_ECOLI (313 aa), 90% identity in 309 aa overlap.
    
  0.907
hpcB
Similar to Escherichia coli 3,4-dihydroxyphenylacetate 2,3-dioxygenase hpcB SW:HPCB_ECOLI (Q05353) fasta scores: E(): 0, 92.3% id in 259 aa.
  
 
 0.905
STY1696
Riboflavin synthase alpha chain; Orthologue of E. coli ribE (RISA_ECOLI); Fasta hit to RISA_ECOLI (213 aa), 90% identity in 209 aa overlap.
    
  0.903
STY3609
Conserved hypothetical protein; Orthologue of E. coli yigB (YIGB_ECOLI); Fasta hit to YIGB_ECOLI (238 aa), 87% identity in 238 aa overlap.
     
 0.900
aphA
Class B acid phosphatase precursor; Dephosphorylates several organic phosphate monoesters including monophosphate nucleotides (NMPs), coenzyme A (CoA), nicotinamide adenine dinucleotide phosphate (NADP), flavin mononucleotide (FMN) and phosphorylated 5-6 carbon sugars in vitro. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity).
     
  0.900
phoN
Similar to Salmonella typhimurium nonspecific acid phosphatase precursor phoN SW:PHON_SALTY (P26976) (250 aa) fasta scores: E(): 0, 94.8% id in 250 aa.
     
  0.900
hpcR
Similar to Escherichia coli homoprotocatechuate degradative operon repressor hpcR or hpaR SW:HPCR_ECOLI (Q07095) fasta scores: E(): 0, 80.1% id in 136 aa.
 
   
 0.603
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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